Results 21 to 30 of about 55,550 (98)

miR-378a-5p and miR-630 induce lens epithelial cell apoptosis in cataract via suppression of E2F3

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2020
Cataract, an eye disease that threatens the health of millions of people, brings about severe economic burden for patients and society. MicroRNA (miR)-378a-5p and miR-630 were recognized as essential regulators in multiple cancers.
Weiwei Gao, Xiaoqing Zhou, Rui-Xin Lin
semanticscholar   +1 more source

Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2

Acta Pharmaceutica Sinica B, 2019
Renal cell carcinoma (RCC) is one of the most common malignant tumors affecting the urogenital system, accounting for 90% of renal malignancies. Traditional chemotherapy options are often the front-line choice of regimen in the treatment of patients with
Luxi Chen, Le Chen, Zhiyuan Qin, Jinxiu Lei, Sheng Ye, K. Zeng, Hua Wang, Meidan Ying, Jianqing Gao, S. Zeng, Lushan Yu   +10 more
semanticscholar   +1 more source

Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary

International Journal of Molecular Sciences, 2019
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme ...
D. A. Nikishin, N. M. Alyoshina, M. Semenova, Y. B. Shmukler   +3 more
semanticscholar   +1 more source

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Using structure-based drug design, we have identified a series of potent allosteric protein–protein interaction acetyl-CoA carboxylase inhibitors, exemplified by ND-630, that interact within the acetyl-CoA carboxylase subunit phosphopeptide ...
G. Harriman, J. Greenwood, Sathesh Bhat, Xinyi Huang, Ruiying Wang, D. Paul, L. Tong, A. Saha, W. Westlin, R. Kapeller, H. J. Harwood   +10 more
semanticscholar   +1 more source

Evaluation of a 27-gene inherited cancer panel across 630 consecutive patients referred for testing in a clinical diagnostic laboratory

Hereditary Cancer in Clinical Practice, 2018
Extensive clinical and genetic heterogeneity of inherited cancers has allowed multi-gene panel testing to become an efficient means for identification of patients with an inherited predisposition to a broad spectrum of syndromic and nonsyndromic forms of
Sabrina A. Gardner, K. Weymouth, W. S. Kelly, E. Bogdanova, Wenjie Chen, Daniel S. Lupu, Joshua A. Suhl, Q. Zeng, U. Geigenmüller, Debbie Boles, Patricia M. Okamoto, G. McDowell, M. Hayden, N. Nagan   +13 more
semanticscholar   +1 more source

The expression of cerebrospinal fluid exosomal miR-630 plays an important role in the dysfunction of endothelial cells after subarachnoid hemorrhage

Scientific Reports, 2019
The purpose of this study was to evaluate the relationship of brain microvascular endothelial cell (BMECs) function and the exosomal miR-630 expression after subarachnoid hemorrhage (SAH).
Leitao Sun, Wensheng Zhang, Zefu Li, M. Li, Jiwei Guo, Hongyan Wang, Xiaohong Wang   +6 more
semanticscholar   +1 more source

A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM

Nature Methods, 2021
C. Bohrer, Xinxing Yang, Shreyasi Thakur, Xiaoli Weng, Brian Tenner, Ryan J. McQuillen, Brian L. Ross, Matthew Wooten, Xin Chen, Jin Zhang, Elijah Roberts, M. Lakadamyali, Jie Xiao   +12 more
semanticscholar   +1 more source

Pivotal roles of Kupffer cells in the progression and regression of DDC-induced chronic cholangiopathy

Scientific Reports, 2018
Kupffer cells (KCs) are key players in maintaining tissue homeostasis and are involved in various liver diseases. However, the roles of KCs in the pathogenesis of cholangiopathy are largely unknown.
Leila Jemail, Masashi Miyao, H. Kotani, C. Kawai, Hirozo Minami, H. Abiru, Keiji Tamaki   +6 more
semanticscholar   +1 more source

A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop

Theranostics, 2018
Purpose: MicroRNA-630 plays dual roles in apoptosis and drug resistance in human cancers. However, the role of miR-630 in resistance to tyrosine kinase inhibitors (TKIs) in lung adenocarcinoma remains to be elucidated.
De-Wei Wu, Yao-Chen Wang, Lee Wang, Chih‐Yi Chen, Hue Lee   +4 more
semanticscholar   +1 more source

The Potential Role of Cyclopeptides from Pseudostellaria heterophylla, Linum usitatissimum and Drymaria diandra, and Peptides Derived from Heterophyllin B as Dipeptidyl Peptidase IV Inhibitors for the Treatment of Type 2 Diabetes: An In Silico Study. [PDF]

Metabolites, 2022
Liao HJ, Tzen JTC.
europepmc   +1 more source