Results 111 to 120 of about 190,243 (246)
Organ Donation After Medical Aid in Dying: An Ethical Overview
Bioethics, EarlyView.ABSTRACT Organ Donation after Medical Aid in Dying (OD‐MAiD) is currently practised in four countries: Belgium, Canada, the Netherlands, and Spain. While OD‐MAiD shares some similarities with MAiD (absent the possibility of organ donation) and with standard organ donation protocols, the combination of OD and MAiD involves unique circumstances that ...
David Rodríguez‐Arias +5 more
wiley +1 more source
A11 Peptide Enhances Radiosensitivity by Degrading EphA2 in Nasopharyngeal Carcinoma
Cancer Science, EarlyView.In EphA2‐high‐expressing nasopharyngeal carcinoma cells, radiation triggers RSK‐dependent phosphorylation of EphA2 at Ser897, which in turn activates AKT and promote radioresistance. The A11 peptide breaks this signaling cascade by degrading EphA2 and blocking its S897 phosphorylation, thereby markedly enhancing radiosensitivity.
Ming Zhang +5 more
wiley +1 more source
Cancer Science, EarlyView.We uncovered pronounced and heterogeneous tumor senescence in EOCRC, independent of age. By integrating multi‐omics and single‐cell analyses, we developed EO‐Senscore, a prognostic tool that stratifies patients by immune phenotype and therapy response, enabling precision treatment using immunotherapy or senolytic agents. ABSTRACT Early‐onset colorectal
Du Cai +11 more
wiley +1 more source
Azapolymethinfarbstoffe durch nucleophile Substitution am Stickstoff
CHIMIA, 1966 B. Hirsch, E.-A. Jauer, B.N. Baijal
doaj +1 more source
Cancer Science, EarlyView.Using integrated spatial pathomics and transcriptomics, we show that neoadjuvant therapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) induces substantial tumor microenvironment remodeling that is not captured by tumor regression grading (TRG) alone.
Xiaofei Zhang +16 more
wiley +1 more source
Über die drucklose Hydrierung von 3-Cyanpyridin
CHIMIA, 1969 Eberhard Fischer +2 more
doaj +1 more source
The FEBS Journal, EarlyView.CellMorph is a groundbreaking tool that allows researchers to analyze multiple features from single cells, including cell size and shape, cytosolic staining and subcellular texture, nuclear staining, and morphometry. By evaluating images from both bright‐field and fluorescence microscopy, it also tracks changes in living cells during key processes such
Henrique Quaiato de Oliveira +16 more
wiley +1 more source
JTAM (Jurnal Teori dan Aplikasi Matematika)Computational Thinking (CT) has emerged as a crucial and foundational skill in the 21st century, capturing the attention of researchers across various domains, including mathematics education in Indonesia.
Edi Irawan +2 more
doaj +1 more source
Beyond the Wall: Typography from the German Democratic Republic [PDF]
, 2004 1989: The German Democratic Republic (GDR) still existed and the Berlin Wall was still standing. Communism was alive in Europe. Hard to believe now, yet only fifteen years ago, a reality.
Carruthers, Grant, Yee, Joyce
core
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source