Results 71 to 80 of about 190,243 (246)

The relevance of schizotypal traits for understanding interpersonal functioning in adolescents with psychiatric problems. [PDF]

, 2017
A
De Clercq, Barbara, Hutsebaut, Joost, van Aken, Marcel AG, Van der Heijden, Paul, Verbeke, Lize   +4 more
core   +2 more sources

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Bildungsreform in der DDR zwischen "pädagogischer Erneuerung der Schule" und deutsch-deutscher Bildungsunion [PDF]

, 1990
Während das Bildungswesen der DDR und speziell die allgemeinbildende Schule offiziell stets als besonders erfolgreich und vorbildlich ausgegeben wurde, änderte sich diese Einschätzung nach der politischen Wende im Herbst 1989 schrittweise.
Schmidt, Gerlind
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Aerial Imagery Redefined: Next-Generation Approach to Object Classification

Information
Identifying and classifying objects in aerial images are two significant and complex issues in computer vision. The fine-grained classification of objects in overhead images has become widespread in various real-world applications, due to recent ...
Eran Dahan, Itzhak Aviv, Tzvi Diskin
doaj   +1 more source

Trust and glycemic control in black patients with diabetic retinopathy: A pilot study [PDF]

, 2019
Diabetic retinopathy (DR) is more prevalent in blacks than whites because, compared to whites, blacks on average have worse glycemic control. Both of these racial disparities reflect differences in sociocultural determinants of health, including ...
Casten, Robin J., Rovner, Barry W.
core   +1 more source

One-dimensional Chern-Simons theory and the $\hat{A}$ genus

, 2013
We construct a Chern-Simons gauge theory for dg Lie and L-infinity algebras on any one-dimensional manifold and quantize this theory using the Batalin-Vilkovisky formalism and Costello's renormalization techniques.
Berline, Bernšteĭn, Bezrukavnikov, Costello, Căldăraru, Fedosov, Fedosov, Frenkel, Gel’fand, Gel’fand, Getzler, Hirzebruch, Hirzebruch, Illusie, Owen Gwilliam, Ryan Grady, Tsygan, Windey   +17 more
core   +1 more source

An evaluation of DNA-damage response and cell-cycle pathways for breast cancer classification [PDF]

, 2014
Accurate subtyping or classification of breast cancer is important for ensuring proper treatment of patients and also for understanding the molecular mechanisms driving this disease.
Fard, Atefeh Taherian, Ragan, Mark A., Srihari, Sriganesh   +2 more
core   +5 more sources

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source