Results 121 to 130 of about 59,976,998 (309)
, 2017 List of contigs generated from the de novo assembly in CLC Genomics ...
John Sproul (3482006) +3 more
core +1 more source
Advanced Science, EarlyView.A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen +15 more
wiley +1 more source
BMC Bioinformatics, 2017 Background The accuracy of metagenomic assembly is usually compromised by high levels of polymorphism due to divergent reads from the same genomic region recognized as different loci when sequenced and assembled together.
You-Yu Lin +7 more
doaj +1 more source
, 2017 List of contigs generated from the de novo assembly in CLC Genomics ...
John Sproul (3482006) +3 more
core +1 more source
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
GRASShopPER – a tool for de novo assembly
, 2019 Second generation sequencers produce billions of short DNA sequences in a massively parallel manner, which causes a great computational challenge in accurately reconstructing a genome sequence de novo using these short sequences. We propose GRASShopPER, GPU overlap GRaph ASSembler using Paired End Reads, which follows an approach of overlap-layout ...
Swiercz, Aleksandra +6 more
openaire +1 more source
, 2017 List of contigs generated from the de novo assembly in CLC Genomics ...
John Sproul (3482006) +3 more
core +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
, 2017 List of contigs generated from the de novo assembly in CLC Genomics ...
John Sproul (3482006) +3 more
core +1 more source
Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus
Advanced Science, EarlyView.Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto +5 more
wiley +1 more source