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Continuous deacetylation of cephalosporins

Biotechnology and Bioengineering, 1980
AbstractContinuous deacetylation of cephalosporin C, 7‐aminocephalosporanic acid, and of 2‐methoxyethyl acetate in packed beds of an immobilized esterase is described by simple empirical equations relating conversion to space velocity and temperature.
Jan, Konecny, M, Sieber
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Enzymatic deacetylation of histone

Biochemical and Biophysical Research Communications, 1969
Abstract An enzyme activity which catalyzed the deacetylation of histone was found in the calf thymus extract. 14 C-Acetyl-histone prepared by incubating calf thymus nuclei with sodium 14 C-acetate served as the substate and treatment of the histone with pronase destroyed most of the susceptibility to the enzymatic deacetylation.
A, Inoue, D, Fujimoto
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Chitin deacetylation by enzymatic means: monitoring of deacetylation processes

Carbohydrate Research, 1995
Abstract A method for monitoring enzymatic deacetylation processes of natural or artificial chitin substrates as well as N-acetylchitooligosaccharides by the direct determination of the acetate released is described. Furthermore, a new assay is presented for the determination of chitin deacetylase activity employing hexa-N-acetylchitohexaose [(GlcNAc)
A. Martinou   +2 more
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Deacetylation of β‐chitin. I. Influence of the deacetylation conditions

Journal of Applied Polymer Science, 2004
AbstractThe influences of the deacetylation temperature, deacetylation time, and NaOH concentration on the degree of deacetylation (DD) of deacetylated products prepared from β‐chitin are discussed. The DD values of deacetylated products are related to the ratio of the signal intensities of methyl on acetyl groups and the first anomeric carbon, which ...
Cheng‐Ho Chen   +2 more
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Sirtuin 3 Mediates Tau Deacetylation

Journal of Alzheimer's Disease, 2019
Background: Emerging evidence shows tau acetylation has been observed in Alzheimer’s disease (AD) brain at early Braak stages and is involved in regulating tau early accumulation. However, the effects of deacetylase Sirtuin 3 (Sirt3) on tau acetylation and its aggregations are unclear.
Shiping, Li   +5 more
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Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges

Carbohydrate Polymers, 2021
Chitin/chitosan hemostatic materials have long been studied for uncontrolled hemorrhage, an urgent clinical problem due to severe blood-vessel damage or hemophilia. As one of the basic structural parameters of chitin, the degree of deacetylation (DD) significantly affects the material's physical, chemical, as well as biological properties.
Xiaoqiang, Song   +6 more
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Determination of Protein Lysine Deacetylation

Current Protocols in Protein Science, 2008
AbstractHistone deacetylases (HDACs) are members of a diverse family of enzymes that catalyze the removal of an acetyl moiety from an acetyl‐lysine‐containing substrate. HDACs target a variety of substrates, including histone and nonhistone proteins, to mediate alterations in protein localization, stability, and activity.
Danielle J P, Ellis   +2 more
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Dynamic Deacetylation

Science Signaling, 2009
Proper regulation of acetylation of the nuclear receptor FXR is lost in metabolic disease.
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