Results 91 to 100 of about 37,077 (255)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

HEIDEGGER AND INDIAN THINKING: THE HERMENEUTIC OF A “BELONGING-TOGETHER” OF NEGATION AND AFFIRMATION [PDF]

, 2015
: According to Heidegger the questioning of Being is unique to western philosophical tradition, however we see that the hermeneutic of Being is explicit in inter-cultural context of thinking. Understanding Brahman as “one ” and “the same ” Śankara speaks
VALLOORAN, Jaison D.
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

System Identification and Navigation of an Underactuated Underwater Vehicle Based on LSTM

Journal of Marine Science and Engineering
Modeling and system identification are critical for the design, simulation, and navigation of underwater vehicles. This study presents a six degree-of-freedom (DoF) nonlinear model for a finless underactuated underwater vehicle, incorporating port ...
Changhao Li, Zetao Hu, Desheng Zhang, Xin Wang   +3 more
doaj   +1 more source

A Novel Framework for Online Amnesic Trajectory Compression in Resource-constrained Environments

, 2016
State-of-the-art trajectory compression methods usually involve high space-time complexity or yield unsatisfactory compression rates, leading to rapid exhaustion of memory, computation, storage and energy resources. Their ability is commonly limited when
Jurdak, Raja, Kusy, Brano, Lee, Jae-Gil, Liu, Jiajun, Shang, Shuo, Sommer, Philipp, Zhao, Kun   +6 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Subway location method based on SINS/DR integrated navigation and map-matching technology

Journal of Measurement Science and Instrumentation, 2017
With the development of rail transit,subway is playing an increasingly important role in peoples daily life.The positioning technology of subway is the key of communication based on train control system（CBTC）.Considering that the global positioning ...
XU Chen, CHEN Guang-wu, FAN Ze-yuan, LIU She-de   +3 more
doaj  

LiDAR Scan Matching Aided Inertial Navigation System in GNSS-Denied Environments

Sensors, 2015
A new scan that matches an aided Inertial Navigation System (INS) with a low-cost LiDAR is proposed as an alternative to GNSS-based navigation systems in GNSS-degraded or -denied environments such as indoor areas, dense forests, or urban canyons.
Jian Tang, Yuwei Chen, Xiaoji Niu, Li Wang, Liang Chen, Jingbin Liu, Chuang Shi, Juha Hyyppä   +7 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source