Results 61 to 70 of about 37,077 (255)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Accurate In-Motion Initial Heading Alignment for Underwater Robots Using a Basis of the Initial Position-Error Space

Journal of Marine Science and Engineering
Accurate initial heading alignment is crucial for autonomous underwater vehicles (AUVs) relying on dead-reckoning (DR) navigation. The multiple GNSS position-based alignment (MGPA) method, using standard point positioning (SPP) GNSS, is an applicable ...
Kihwan Choi, Hyoungjoo Kang, Yun-Ho Ko, Jihong Lee   +3 more
doaj   +1 more source

Control of unmanned aerial vehicle modules based on inertial measurement system and MEMS sensor [PDF]

MATEC Web of Conferences
This article examines the effect of crosswind on the deflection of UAV cargo in free fall, taking into account the parameters of air resistance and drag coefficient. The displacement results are obtained graphically through simulation. The diagram of the
Boiko Juliy, Svachii Oleh, Kałaczyński Tomasz   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Quantitative Assessment of Upper Limb Motion in Neurorehabilitation Utilizing Inertial Sensors [PDF]

, 2015
Two inertial sensor systems were developed for 3-D tracking of upper limb movement. One utilizes four sensors and a kinematic model to track the positions of all four upper limb segments/joints and the other uses one sensor and a dead reckoning algorithm
Bai, Lu, Pepper, Matthew G., Phillips, Malcolm, Sakel, Mohamed, Spurgeon, Sarah K., Yan, Yong   +5 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Visual Tracking in Unknown Environments Using Fuzzy Logic and Dead Reckoning

International Journal of Advanced Robotic Systems, 2016
This paper addresses the problem of making a non-holonomic wheeled mobile robot (WMR) move to a target object using computer vision and obstacle-avoidance techniques. If a priori information about the obstacles is available, pre-planning the desired path
Mohamed Amine Mekhtiche, Zoubir Abdeslem Benselama, Mohamed Abdelkader Bencherif, Mohammed Zakariah, Mansour Alsulaiman, Ramdane Hedjar, Mohammed Faisal, Mohammed Algabri, Khalid AlMuteb   +8 more
doaj   +1 more source

Modular HLA RTI services: The GRIDS approach [PDF]

, 2002
The Generic Runtime Infrastructure for Distributed Simulation (GRIDS) has been developed to investigate modularity issues in distributed simulation.
Sudra, R, Taylor, S J E
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source