Results 121 to 130 of about 10,693,133 (406)

High Death Rates: More Deaths or Earlier Deaths?

Journal of the Royal College of Physicians of London, 1987
In the analysis of mortality statistics high age-specific death rates could be interpreted as meaning more deaths (more disease), but they could equally well be interpreted as meaning earlier deaths (death at younger age). The distinction markedly affects the choice of hypotheses that may be advanced to explain variations in person, time and place and ...
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

New insights into regulatory cell death and acute pancreatitis [PDF]

, 2023
Hongyao Li, Ding Wu, Haidan Zhang, Peiwu Li   +3 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice [PDF]

, 2023
Hyoseon Oh, Suho Lee, Yusang Oh, Seongbin Kim, Young Seo Kim, Yeji Yang, Woochul Choi, Ye-Eun Yoo, Heejin Cho, Seungjoon Lee, Esther Yang, Wuhyun Koh, Woojin Won, Ryunhee Kim, C. Justin Lee, Hyun Kim, Hyojin Kang, Jin Young Kim, Taeyun Ku, Se‐Bum Paik, Eunjoon Kim   +20 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

BECLIN-1 is essential for the maintenance of gastrointestinal epithelial integrity by regulating endocytic trafficking, F-actin organization, and lysosomal function

Autophagy Reports
Disrupted intestinal homeostasis and barrier function contribute to the development of diseases such as inflammatory bowel disease. BECLIN-1, a core component of two class III phosphatidylinositol 3 kinase complexes, has a dual role in autophagy and ...
Juliani Juliani, Sharon Tran, Tiffany J. Harris, Peter De Cruz, Sarah L. Ellis, Paul A. Gleeson, John M. Mariadason, Kinga Duszyc, Alpha S. Yap, Erinna F. Lee, Walter D. Fairlie   +10 more
doaj   +1 more source

From the Dissolution of the Anima to the End of All Things [PDF]

, 2018
In the present paper I analyze the theme of death in Gothic Metal songs such as Forever Failure by Paradise Lost, Everything Dies by Type O Negative, The Hanged Man by Moonspell or Gone with The Sin by HIM. The subthemes I am mostly interested in are the
Bolea, Ștefan
core   +1 more source

Mechanism and Regulation of Gasdermin-Mediated Cell Death [PDF]

, 2019
Shiyu Xia, Louis Hollingsworth, Hao Wu
openalex   +1 more source

Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death [PDF]

, 2020
Gabriel Laghlali, Kate E. Lawlor, Michelle D. Tate   +2 more
openalex   +1 more source