Results 21 to 30 of about 2,794,922 (242)

Life and death by death receptors

The FASEB Journal, 2009
ABSTRACT Death receptors are members of the tumor necrosis factor receptor superfamily characterized by a cytoplasmic region known as the “death domain” that enables the receptors to initiate cytotoxic signals when engaged by cognate ligands. Binding to the ligand results in receptor aggregation and recruitment of
Maria Eugenia, Guicciardi, Gregory J, Gores   +1 more
openaire   +3 more sources

Targeting the Interaction of GABAB Receptors With CHOP After an Ischemic Insult Restores Receptor Expression and Inhibits Progressive Neuronal Death

Frontiers in Pharmacology, 2022
GABAB receptors control neuronal excitability via slow and prolonged inhibition in the central nervous system. One important function of GABAB receptors under physiological condition is to prevent neurons from shifting into an overexcitation state which ...
Musadiq A. Bhat, Abolghasem Esmaeili, Elena Neumann, Karthik Balakrishnan, Dietmar Benke, Dietmar Benke, Dietmar Benke   +6 more
doaj   +1 more source

Cross Kingdom Immunity: The Role of Immune Receptors and Downstream Signaling in Animal and Plant Cell Death

Frontiers in Immunology, 2021
Both plants and animals are endowed with sophisticated innate immune systems to combat microbial attack. In these multicellular eukaryotes, innate immunity implies the presence of cell surface receptors and intracellular receptors able to detect danger ...
Thibault Roudaire, Marie-Claire Héloir, David Wendehenne, Aymeric Zadoroznyj, Aymeric Zadoroznyj, Laurence Dubrez, Laurence Dubrez, Benoit Poinssot   +7 more
doaj   +1 more source

A Mechanism for Death Receptor Discrimination by Death Adaptors [PDF]

Journal of Biological Chemistry, 2005
The death domain and death effector domain are two common motifs that mediate protein-protein interactions between components of cell death signaling complexes. The mechanism by which these domains engage their binding partners has been explored by extensive mutagenesis of two death adaptors, FADD and TRADD, suggesting that a death adaptor can ...
Cristinel, Sandu, Evripidis, Gavathiotis, Ted, Huang, Iga, Wegorzewska, Milton H, Werner   +4 more
openaire   +2 more sources

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Cartwright, JE, Aplin, JD, Whitley, GS, Keogh, RJ, Freeman, A, Harris, LK, Baker, PN   +6 more
core   +1 more source

Interactive Effects of HDAC Inhibitors and TRAIL on Apoptosis Are Associated with Changes in Mitochondrial Functions and Expressions of Cell Cycle Regulatory Genes in Multiple Myeloma

Neoplasia: An International Journal for Oncology Research, 2005
In this study, we have evaluated the cytotoxic effect of combining two HDAC inhibitors, SAHA and TSA, with TRAIL in human multiple myeloma cell lines.
Tamer E. Fandy, Sharmila Shankar, Douglas D. Ross, Edward Sausville, Rakesh K. Srivastava   +4 more
doaj   +1 more source

Death receptors as targets in cancer [PDF]

British Journal of Pharmacology, 2013
Anti‐tumour therapies based on the use pro‐apoptotic receptor agonists, including TNF‐related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or TRAIL‐R2, have been disappointing so far, despite clear evidence of clinical activity and lack of adverse events for the vast majority of these compounds, whether combined or not ...
Micheau, Olivier, Shirley, Sarah, Dufour, Florent   +2 more
openaire   +3 more sources

PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma

OncoImmunology, 2018
Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased capacities of proliferation, invasion and have the ability to generate metastases by escaping the immune system during their systemic migration.
A. Asgarova, K. Asgarov, Y. Godet, P. Peixoto, A. Nadaradjane, M. Boyer-Guittaut, J. Galaine, D. Guenat, V. Mougey, J. Perrard, J. R. Pallandre, A. Bouard, J. Balland, C. Tirole, O. Adotevi, E. Hendrick, M. Herfs, P. F. Cartron, C. Borg, E. Hervouet   +19 more
doaj   +1 more source

Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation

Frontiers in Pharmacology, 2019
Erinacine A, which is one of the major bioactive diterpenoid compounds extracted from cultured mycelia of H. erinaceus, displays great antitumorigenic activity.
Ko-Chao Lee, Ko-Chao Lee, Kam-Fai Lee, Shui-Yi Tung, Shui-Yi Tung, Wen-Shih Huang, Wen-Shih Huang, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chih-Chuan Teng, Chih-Chuan Teng, Chien-Heng Shen, Chien-Heng Shen, Meng-Chiao Hsieh, Meng-Chiao Hsieh, Hsing-Chun Kuo, Hsing-Chun Kuo, Hsing-Chun Kuo, Hsing-Chun Kuo   +19 more
doaj   +1 more source

TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors

Drug Delivery, 2017
Active targeting nanoparticles were developed to simultaneously codeliver tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Curcumin (Cur).
Xi Yang, Zhaojun Li, Qinjie Wu, Shouchun Chen, Cheng Yi, Changyang Gong   +5 more
doaj   +1 more source