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Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Modulation of Host Cell Death Signaling Platforms by <i>Plasmodium falciparum</i>: Implications for Eryptosis Regulation and Parasite Survival. [PDF]

Cells
Solís-Castillero L, Correa R, Alves-Rosa MF, Spadafora C.   +3 more
europepmc   +1 more source

Helping Apo2L/TRAIL in the Battle: Synergistic Therapeutic Approaches for Cancer Therapies. [PDF]

Int J Mol Sci
Fuior EV, Dumitrescu M, Multescu MG, Daraban BS, Ghinea M, Mirancea O, Petrescu GED, Brehar FM, Vacaru AM, Ionita R, Bivol VG, Tudorache IF, Popa A, Fenyo IM, Zvintzou E, Gafencu AV.   +15 more
europepmc   +1 more source

TAMing the tumor: targeting immune inhibitory receptors on tumor-associated macrophages in pediatric brain tumors - an emerging immunotherapy strategy. [PDF]

J Immunother Cancer
Mooij L, Meesters-Ensing JI, Calkoen FG, van der Lugt J, Meyaard L, Nierkens S, Carvalheiro T.   +6 more
europepmc   +1 more source

Role of post-translational modifications in modulating histone reactivity in the extracellular environment. [PDF]

Biochem Soc Trans
Hemmling H, Hawkins CL.
europepmc   +1 more source

Recent advances in PANoptosis research in kidney disease: mechanistic networks, pathological roles, and potential intervention strategies. [PDF]

Front Immunol
Yang S, Li X, Zhang C, Ma S, Zhou Y.
europepmc   +1 more source

Apoptosis induced by death receptors

Pharmaceutica Acta Helvetiae, 2000
Death receptors belong to the TNF receptor family and are characterised by an intracellular death domain that serves to recruit adapter proteins such as TRADD and FADD and cysteine proteases such as Caspase-8. Activation of Caspase-8 on the aggregated receptor leads to apoptosis. Triggering of death receptors is mediated through the binding of specific
Pascal Schneider, J Tschopp
exaly   +6 more sources

Death Receptors: Signaling and Modulation

Science, 1998
REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface.
Vishva Dixit, Avi Ashkenazi
exaly   +4 more sources

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Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors

Biochemical and Biophysical Research Communications, 2005
Death receptors (DRs) can induce apoptosis by oligomerization with TRAIL, whereas death decoy receptors (DcRs) cannot, due to their lack of functional intracellular death domains. However, it is not known whether DRs and DcRs can interact with one another to form oligomeric complexes prior to TRAIL binding.
Myung-Hee Kwon, Yong-Sung Kim
exaly   +3 more sources

The Death Receptors

1999
In recent years apoptosis, also called programmed cell death, has been recognized to be the physiological way for a nucleated animal cell to die. Apoptosis takes care of unwanted, injured or virus-infected cells (Farber 1994; Collins 1995). Autoreactive T and B cells that are produced by the immune system by the millions every day are also eliminated ...
Peter, M. E., Scaffidi, C., Medema, J. P., Kischkel, F., Krammer, P. H.   +4 more
openaire   +4 more sources