Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes. [PDF]
Sci Rep, 2017 Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients. The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood.
Zhao L, Zhang B.
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Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors. [PDF]
Mol Cell Biol, 2017 Metabolic stress occurs frequently in tumors and in normal tissues undergoing transient ischemia. Nutrient deprivation triggers, among many potential cell death-inducing pathways, an endoplasmic reticulum (ER) stress response with the induction of the ...
Iurlaro R +7 more
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Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis. [PDF]
Mediators Inflamm, 2016 Seizure models have demonstrated that neuroinflammation and neurodegeneration are preponderant characteristics of epilepsy. Considering the lack of clinical studies, our aim is to investigate the extrinsic pathway of apoptosis in pharmacoresistant ...
Teocchi MA, D'Souza-Li L.
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The Association of Death Receptors and TGF-β1 Expression in Urothelial Bladder Cancer and Their Prognostic Significance [PDF]
BiomedicinesDeath receptor signalization that triggers the extrinsic apoptotic pathway and TGF-β1 have important roles in urothelial carcinogenesis, with a complex interplay between them. The aim of this research was to assess the association of death receptors DR4,
Slavica Stojnev +6 more
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Spatial dynamics of TRAIL death receptors in cancer cells
Drug Resistance Updates, 2015 TNF-related apoptosis inducing ligand (TRAIL) selectively induces apoptosis in cancer cells without harming most normal cells. Currently, multiple clinical trials are underway to evaluate the antitumor activity of recombinant human TRAIL (rhTRAIL) and ...
J. Twomey +4 more
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Membrane trafficking of death receptors: implications on signalling. [PDF]
Int J Mol Sci, 2013 Death receptors were initially recognised as potent inducers of apoptotic cell death and soon ambitious attempts were made to exploit selective ignition of controlled cellular suicide as therapeutic strategy in malignant diseases. However, the complexity
Schneider-Brachert W +2 more
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Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
Frontiers in Immunology, 2018 Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns—PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular ...
Gustavo P. Amarante-Mendes +9 more
doaj +2 more sources
Regulation of anoikis by extrinsic death receptor pathways
Cell Communication and Signaling, 2023 Metastatic cancer cells can develop anoikis resistance in the absence of substrate attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria-dependent and exogenous death receptor pathways, and studies have shown that caspase-
Ying-Hao Han +5 more
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Editorial: Death Receptors, Non-apoptotic Signaling Pathways and Inflammation [PDF]
Frontiers in Immunology, 2020 Eva Szegezdi, Patrick Legembre
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Cell death‐independent activities of the death receptors CD95, TRAILR1, and TRAILR2
FEBS Journal, 2017 Harald Wajant
exaly +2 more sources