Results 31 to 40 of about 5,657,584 (240)

Targeting the Interaction of GABAB Receptors With CHOP After an Ischemic Insult Restores Receptor Expression and Inhibits Progressive Neuronal Death

Frontiers in Pharmacology, 2022
GABAB receptors control neuronal excitability via slow and prolonged inhibition in the central nervous system. One important function of GABAB receptors under physiological condition is to prevent neurons from shifting into an overexcitation state which ...
Musadiq A. Bhat, Abolghasem Esmaeili, Elena Neumann, Karthik Balakrishnan, Dietmar Benke, Dietmar Benke, Dietmar Benke   +6 more
doaj   +1 more source

Cross Kingdom Immunity: The Role of Immune Receptors and Downstream Signaling in Animal and Plant Cell Death

Frontiers in Immunology, 2021
Both plants and animals are endowed with sophisticated innate immune systems to combat microbial attack. In these multicellular eukaryotes, innate immunity implies the presence of cell surface receptors and intracellular receptors able to detect danger ...
Thibault Roudaire, Marie-Claire Héloir, David Wendehenne, Aymeric Zadoroznyj, Aymeric Zadoroznyj, Laurence Dubrez, Laurence Dubrez, Benoit Poinssot   +7 more
doaj   +1 more source

Interactive Effects of HDAC Inhibitors and TRAIL on Apoptosis Are Associated with Changes in Mitochondrial Functions and Expressions of Cell Cycle Regulatory Genes in Multiple Myeloma

Neoplasia: An International Journal for Oncology Research, 2005
In this study, we have evaluated the cytotoxic effect of combining two HDAC inhibitors, SAHA and TSA, with TRAIL in human multiple myeloma cell lines.
Tamer E. Fandy, Sharmila Shankar, Douglas D. Ross, Edward Sausville, Rakesh K. Srivastava   +4 more
doaj   +1 more source

The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production.

Free Radical Biology & Medicine, 2017
Ligation of the death receptors for TNF-α, FasL, and TRAIL triggers two common pathways, caspase-dependent intrinsic apoptosis and intracellular reactive oxygen species (ROS) generation.
Wan-Sung Kim, K. Lee, Ji-Hee Kim, C. Kim, Gwangsoon Lee, J. Choe, M. Won, Tae-Hyoung Kim, D. Jeoung, Hansoo Lee, Ji-Yon Kim, Mi Ae Jeong, K. Ha, Young-Guen Kwon, Young-Myeong Kim   +14 more
semanticscholar   +1 more source

PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma

OncoImmunology, 2018
Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased capacities of proliferation, invasion and have the ability to generate metastases by escaping the immune system during their systemic migration.
A. Asgarova, K. Asgarov, Y. Godet, P. Peixoto, A. Nadaradjane, M. Boyer-Guittaut, J. Galaine, D. Guenat, V. Mougey, J. Perrard, J. R. Pallandre, A. Bouard, J. Balland, C. Tirole, O. Adotevi, E. Hendrick, M. Herfs, P. F. Cartron, C. Borg, E. Hervouet   +19 more
doaj   +1 more source

Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation

Frontiers in Pharmacology, 2019
Erinacine A, which is one of the major bioactive diterpenoid compounds extracted from cultured mycelia of H. erinaceus, displays great antitumorigenic activity.
Ko-Chao Lee, Ko-Chao Lee, Kam-Fai Lee, Shui-Yi Tung, Shui-Yi Tung, Wen-Shih Huang, Wen-Shih Huang, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chih-Chuan Teng, Chih-Chuan Teng, Chien-Heng Shen, Chien-Heng Shen, Meng-Chiao Hsieh, Meng-Chiao Hsieh, Hsing-Chun Kuo, Hsing-Chun Kuo, Hsing-Chun Kuo, Hsing-Chun Kuo   +19 more
doaj   +1 more source

A DR4, DR5 Targeting Conjugated TRAIL Treatment for Colorectal Carcinogenesis: A Way to Future? [PDF]

Pharmaceutical Sciences
TRAIL or tumor necrosis factor-related apoptosis-inducing ligand has been one of the major frontiers for the chemotherapeutic approach to treating carcinogenesis.
Parikshit Roychowdhury, Indhumathi Thirugnanasambandham, Anindita De, Mirunalini Gobinath, Samanwita Khanra, Veera Venkata Satyanarayana Reddy Karri, Nihar Ranjan Bhuyan, Gowthamrajan Kuppusamy   +7 more
doaj   +1 more source

Theaflavin-3,3′-Digallate Suppresses Human Ovarian Carcinoma OVCAR-3 Cells by Regulating the Checkpoint Kinase 2 and p27 kip1 Pathways

Molecules, 2019
Theaflavin-3,3′-digallate (TF3) is a unique polyphenol in black tea. Epidemiological studies have proved that black tea consumption decreases the incidence rate of ovarian cancer.
Ying Gao, Junfeng Yin, Youying Tu, Yi Charlie Chen   +3 more
doaj   +1 more source

Role of Glycans on Key Cell Surface Receptors That Regulate Cell Proliferation and Cell Death

Cells, 2021
Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated.
Yin Gao, Xue Luan, Jacob Melamed, Inka Brockhausen   +3 more
doaj   +1 more source

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

Science, 2019
NAD depletion as pathogen response One way that plants respond to pathogen infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive response carry Toll/interleukin-1 ...
Lingwei Wan, Kow Essuman, Ryan G. Anderson, Y. Sasaki, Freddy Monteiro, Eui-Hwan Chung, Erin Osborne Nishimura, A. Diantonio, J. Milbrandt, J. Dangl, Marc T. Nishimura   +10 more
semanticscholar   +1 more source