Results 61 to 70 of about 88,974,747 (261)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

HEART TRANSPLANTATION WITH EXTREMELY EXTENDED COLD ISCHEMIA TIME OF THE DONOR HEART

Вестник трансплантологии и искусственных органов, 2018
Heart transplantation is the gold standard for the treatment of terminal heart failure. The main method of the donor heart preservation is cold perfusion. The recommended maximum time for cold ischemia of the donor heart is 240 minutes.
S. A. Alsov, A. V. Fomichev, D. V. Doronin, V. A. Shmyrev, D. E. Osipov, A. M. Chernyavskiy   +5 more
doaj   +1 more source

Cadaveric blood cards: Assessing DNA quality and quantity and the utility of STRs for the individual estimation of trihybrid ancestry and admixture proportions

Forensic Science International: Synergy, 2020
As part a body donation program, blood samples were collected and stored on untreated (non-FTA) blood cards. The blood cards were evaluated in terms of DNA preservation and STR typing success with resulting profiles assessed with special consideration ...
Frankie L. West, PhD, Bridget F.B. Algee-Hewitt, PhD   +1 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Optimization of ultrastructural preservation of human brain for transmission electron microscopy after long post-mortem intervals

Acta Neuropathologica Communications, 2019
Electron microscopy (EM) provides the necessary resolution to visualize the finer structures of nervous tissue morphology, which is important to understand healthy and pathological conditions in the brain.
Mariella Sele, Stefan Wernitznig, Saška Lipovšek, Snježana Radulović, Johannes Haybaeck, Anna Maria Birkl-Toeglhofer, Christina Wodlej, Florian Kleinegger, Stephan Sygulla, Marlene Leoni, Stefan Ropele, Gerd Leitinger   +11 more
doaj   +1 more source

Ex Situ Arterial Reconstruction During Normothermic Perfusion of the Liver

Transplantation Direct, 2020
Background. Aberrant hepatic arterial anatomy may be seen in up to 30% of liver grafts, and reconstruction prolongs the cold ischemic time or the arterialization times.
David Nasralla, PhD, FRCS, Hanns Lembach, MD, Hynek Mergental, PhD, Darius Mirza, MS, FRCS, Peter Friend, Paolo Muiesan, MD, FRCS, MTPR Perera, MD, FRCS   +6 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

2019 - 2020 Digital Preservation Community Survey

, 2020
The OPF (Open Preservation Foundation) conducted the 2019/2020 community survey between November 2019 and Februrary 2020 and the results provide a detailed picture of the digital preservation landscape today.
Open Preservation Foundation
core   +1 more source

The multifaceted nature of Egyptian mummification: Paleoradiological insights into child mummies.

PLoS ONE
In accordance with ancient Egyptian beliefs, the preservation of the body after death was an important prerequisite for the continued existence of the deceased in the afterlife.
Stephanie Zesch, Stephanie Panzer, Alice Paladin, M Linda Sutherland, Susanne Lindauer, Ronny Friedrich, Tanja Pommerening, Albert Zink, Wilfried Rosendahl   +8 more
doaj   +1 more source