Results 51 to 60 of about 494,604 (306)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Experimental study on the impact of wide graded debris flow on check dam in high altitude area
Shuiwen dizhi gongcheng dizhiThe impact force of debris flow is the main cause of damage and destruction of check dam. In high altitude area, due to high mountains and deep valleys, serious physical weathering of surface materials, a wide range of source materials gradation, high ...
Shengqing HE, Da ZHENG, Wen ZHANG
doaj +1 more source
An Assessment Method for Debris Flow Dam Formation in Taiwan
Earth Sciences Research Journal, 2018 Debris flows in tributaries rush into and block the main branches of rivers and often result in serious hazards. Dam failures cause large floods in the downstream area and can lead to fatalities and property damage.
Kun-Ting Chen +5 more
doaj +1 more source
Zhongguo dizhi zaihai yu fangzhi xuebao, 2022 Post-fire debris flow is a special torrent containing a large amount of loose material, which is closely related to forest fire. Its characteristics are significantly different from the conventional debris flow.
Xiangbin YANG +6 more
doaj +1 more source
Numerical simulation of debris flows triggered from the Strug rock fall source area, W Slovenia [PDF]
, 2006 The Strug landslide was triggered in December 2001 as a rockslide, followed by a rock fall. In 2002, about 20 debris flows were registered in the Kosec village; they were initiated in the Strug rock fall source area.
Fazarinc, Rok +7 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Frontiers in Earth ScienceDebris flow is a prevalent geological disaster in Beijing, particularly in the Mentougou District, situated in the mountainous southwestern region of Beijing City. The past irrational exploitation of minerals has led to a substantial accumulation of slag,
Yongchao Li +22 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Analysis of debris-flow recordings in an instrumented basin: confirmations and new findings [PDF]
, 2012 On 24 August 2006, a debris flow took place in the Moscardo Torrent, a basin of the Eastern Italian Alps instrumented for debris-flow monitoring. The debris flow was recorded by two seismic networks located in the lower part of the basin and on the ...
L. Marchi, M. Arattano, M. Cavalli
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source