Results 61 to 70 of about 506,489 (355)

Risk Assessment of Debris Flows in Small Watersheds on the Northeast Margin of Qinghai-Tibet Plateau—A Case Study of Zhujiagou Watershed

Lithosphere, 2022
In the Qinghai-Tibet Plateau, fractures and fault zones have developed in this area, where earthquakes and extreme rainfall frequently induce debris flow disasters, which seriously threaten the safety of the people and properties.
Zhanlin Qiu, Weimin Yang, Jihuan Wu, Feipeng Wan, Xuan Zha, Chenyang Liu   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Simulasi Penanganan Potensi Aliran Debris di Gunung Sago (Studi Kasus di Batang Lakin, Kecamatan Lareh Sago Halaban, Kabupaten Lima Puluh Kota) [PDF]

, 2014
The regions in foothills of Sago mountain are flood-prone area due to debris flow. As occurred on March 22, 2010, there has been a catastrophic overflow of debris flow from Sago mountain.
Hadthya, R. \u27. (Reinhart), Sujatmoko, B. \u27. (Bambang), Sutikno, S. (Sigit)   +2 more
core  

Lattice-Boltzmann Method for Geophysical Plastic Flows

, 2015
We explore possible applications of the Lattice-Boltzmann Method for the simulation of geophysical flows. This fluid solver, while successful in other fields, is still rarely used for geotechnical applications.
C. Ancey, C. Körner, C.J. Phillips, C.K. Aidun, C.R. Leonardi, K. Hutter, K.X. Whipple, M. Mendoza, M. Mendoza, O. Švec, P. Coussot, P.L. Bhatnagar, R.M. Iverson, R.M. Iverson, S. Chen, S. Mcdougall, S. Succi, S.B. Savage, T. Takahashi, X. Shan   +19 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The application of numerical debris flow modelling for the generation of physical vulnerability curves [PDF]

, 2011
For a quantitative assessment of debris flow risk, it is essential to consider not only the hazardous process itself but also to perform an analysis of its consequences. This should include the estimation of the expected monetary losses as the product of
B. Quan Luna, C. J. van Westen, J. Blahut, S. O. Akbas, S. Sterlacchini, T. W. J. van Asch   +5 more
core   +8 more sources

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Debris Flow Debris Flow Detection by Combinations of LVP Sensors and Wires: Examples in Sakura-jima Island in Japan

Journal of the Civil Engineering Forum
Various kinds of sensors for debris flows detection have been proposed such as wire sensor, acceleration sensor, and so on. In Europe, a geophone that is based on a vibration meter is usually used though the applicability is not confirmed for debris ...
Takahiro Itoh, Satoshi Tagata, Takahisa Mizuyama   +2 more
doaj   +1 more source

Variable selection based on entropic criterion and its application to the debris-flow triggering [PDF]

, 2006
We propose a new data analyzing scheme, the method of minimum entropy analysis (MEA), in this paper. New MEA provides a quantitative criterion to select relevant variables for modeling the physical system interested. Such method can be easily extended to
Caticha, Chen, Chen, Chen, Chen, Chen, Chien-chih Chen, Chih-Yuan Tseng, Davis, Dupuis, Forbes, Jan, Jaynes, Jaynes, Jaynes, Jia-Jyun Dong, Johnson, Lin, Lin, Lin, Lin, Raftery, Rundle, Rupert, Skilling, Takahashi, Tseng, Weiss, Wieczorek   +28 more
core   +2 more sources