Results 41 to 50 of about 55,099 (261)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

La disrupción de la temporalidad en Volver a dónde, de Antonio Muñoz Molina

open access: yesCuadernos LIRICO
Volver a dónde (2021) is an Antonio Muñoz Molina’s book about the daily life of a homonym narrator during the COVID-19 pandemic and the subsequent new normality.
Ane Matres García
doaj   +1 more source

Variations of High-Intensity GPS Derived Measures between Playing Status during a Full Soccer Season in a Professional Male Team

open access: yesJournal of Men's Health, 2022
Background: This study’s aim was twofold: (i) to compare starters and non-starters on a professional soccer team in terms of variations in training intensity indexes across a season, calculated through total distance, sprint distance, accelerations (Acc),
Hadi Nobari   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

A mathematical model of the vibrating system equivalent to the vehicle in the mode of emergency braking [PDF]

open access: yesTransport, 2003
A mathematical model of the vibrating system equivalent to the vehicle in the mode of emergency braking is developed and the solution is offered. The problem associated with the comparison of the vibrations of the braking vehicle with the oscillations of
R. Pečeliūnas   +2 more
doaj  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Development of Intercity EMUs Brake System

open access: yes机车电传动, 2015
The braking system design proposal on CRH6 intercity EMUs was introduced. According to the transport demand, the difficulty for development of the braking system was analyzed, and the top design indexes for braking system were indentified.
ZHANG Liguo   +4 more
doaj  

La decelerazione pandemica come apertura di potenziali di trasformazione sociale. Alcuni percorsi di teoria critica

open access: yesSocietàMutamentoPolitica: Rivista Italiana di Sociologia, 2023
The global health crisis related to the spread of the Covid-19 pandemic has restored unexpected relevance to certain theoretical schemes that are part of the conceptual heritage of the Frankfurt critical theory.
Giorgio Fazio
doaj  

Kinetics of Decelerated Melting

open access: yesAdvanced Science, 2018
AbstractMelting presents one of the most prominent phenomena in condensed matter science. Its microscopic understanding, however, is still fragmented, ranging from simplistic theory to the observation of melting point depressions. Here, a multimethod experimental approach is combined with computational simulation to study the microscopic mechanism of ...
Wondraczek, Lothar   +9 more
openaire   +4 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

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