Results 111 to 120 of about 15,112 (276)

Bioengineering thymus organoids to restore thymic function and induce donor-specific immune tolerance to allografts [PDF]

, 2015
One of the major obstacles in organ transplantation is to establish immune tolerance of allografts. Although immunosuppressive drugs can prevent graft rejection to a certain degree, their efficacies are limited, transient, and associated with severe side
Alpdogan, Anderson, Anderson, Antonina Coppola, Asako Tajima, Bennett, Bleul, Boehm, Bonfanti, Bonner, Bredenkamp, Bredenkamp, Calderón, Chu, Chung, Corbeaux, De Barros, Depreter, Dudakov, Erickson, Falcon, Fan, Fan, Fan, Fink, Fletcher, Flomerfelt, Foss, Gilbert, Gill, Giulio Gualtierotti, Goh, Goh, Gottrand, Heng, Hogquist, Hsu, Inami, Ipsita Banerjee, Jin, Kermani, Klein, Komori, Krell, Macchiarini, Mali, Manley, Maria Grupillo, Marshall, Massimo Trucco, Mathis, Min, Nitta, Orlando, Ott, Ott, Parent, Petersen, Pinto, Posselt, Poznansky, Quah, Rae, Rita Bottino, Saik Kia Goh, Schechner, Seach, Seach, Shin’oka, Sjöqvist, Song, Sun, Suzanne Bertera, Takada, Thornton, Uygun, van Ewijk, Wekerle, William A Rudert, Wong, Xuehui Geng, Yong Fan, Zartman   +82 more
core   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

The impact of detergents on the tissue decellularization process: a ToF-SIMS study [PDF]

, 2016
Biologic scaffolds are derived from mammalian tissues, which must be decellularized to remove cellular antigens that would otherwise incite an adverse immune response.
Adam J. Taylor, Anderton, Badylak, Baiguera, Barnes, Begum, Bissell, Bolland, Brown, Brown, Brown, Buddy D. Ratner, Canavan, Carlred, Cebotari, Celiz, Crapo, Crapo, Cross, Denver M. Faulk, DeQuach, Faulk, Freytes, Garcia, Gilbert, Gilpin, Glasberg, Golla, Gonfiotti, Graham, Graham, Gratzer, Guo, Harvey, He, Hook, Hudson, Ilea T. Swinehart, Ilin, Israeli, Janet E. Reing, Karabekmez, Keane, Keane, Keane, Keane, Keane, Kundu, Lewis, Lindsey T. Saldin, Lisa J. White, Londono, Mancuso, Mase, Neill J. Turner, Nelson, Nieponice, Ott, Ott, Patel, Petersen, Reing, Remlinger, Ren, Rieder, Santoso, Scriven, Shupe, Sicari, Smith, Stephen F . Badylak, Sullivan, Syed, Taylor, Timothy J. Keane, Uygun, Vavken, Velardi, Wainwright, Wallis, Woods, Wu, Xu, Youngstrom   +83 more
core   +2 more sources

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

Dextran Sulphate Crowding and Sodium Deoxycholate Lysis of Primary Breast Fibroblast Cells Achieve Extracellular Matrix Deposition and Decellularization for Breast Cancer Stem Cell Culture [PDF]

, 2015
Background: The microenvironment including stromal cells and extracellular matrix (ECM) is now consideredan active contributor to tumor progression. Certain studies have developed ECM which supports a suitable cellulargrowth in vitro.
Naruni, A. (Aroem), Ornella, A. (Aulia)
core  

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Towards Safety and Regulation Criteria for Clinical Applications of Decellularized Organ-Derived Matrices

Bioengineering
Whole-organ decellularization generates scaffolds containing native extracellular matrix (ECM) components with preserved tissue microarchitecture, providing a promising advancement in tissue engineering and regenerative medicine.
Elena V. A. van Hengel, Luc J. W. van der Laan, Jeroen de Jonge, Monique M. A. Verstegen   +3 more
doaj   +1 more source

Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds [PDF]

, 2017
Patients with large tracheal lesions unsuitable for conventional endoscopic or open operations may require a tracheal replacement but there is no present consensus of how this may be achieved. Tissue engineering using decellularized or synthetic tracheal
Birchall, M.A. (Martin A.), Burns, A.J. (Alan), Butler, C.R. (Colin R.), Carvalho, C. (Carla), Coppi, P. (Paolo) de, Crowley, C. (Claire), Gowers, K.H.C. (Kate H.C.), Hamilton, N.J. (Nicholas J.), Hynds, R.E. (Robert E.), Janes, S.M. (Sam M.), Lowdell, M.W. (Mark W.), Partington, L. (Leanne), Platé, M. (Manuela), Samuel, E.R. (Edward R.), Urbani, L. (Luca)   +14 more
core   +3 more sources

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, EarlyView.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source

Mechanical characterization of a customized decellularized scaffold for vascular tissue engineering. [PDF]

, 2012
Several challenges persist when attempting to utilize decellularized tissue as a scaffold for vascular tissue engineering. Namely: poor cell infiltration/migration, excessive culture times associated with repopulating the scaffolds, and the achievement ...
Duffy, Garry P, Murphy, B P, Sheridan, W S   +2 more
core   +1 more source