Results 81 to 90 of about 15,112 (276)

Superior Ventriculo-Arterial Coupling with Decellularized Allografts Compared with Conventional Prostheses [PDF]

, 2014
Background To date, no experimental or clinical study provides detailed analysis of vascular impedance changes after total aortic arch replacement. This study investigated ventriculoarterial coupling and vascular impedance after replacement of the aortic
Becher, Peter Moritz, Chaimow, Nicole, Hartyánszky, István, Istók, Roland, Karck, Matthias, Korkmaz, Sevil, Li, Shiliang, Merkely, Béla, Merkely, Gergo, Németh, Balázs Tamás, Pätzold, Ines, Radovits, Tamás, Schmack, Bastian, Soós, Pál, Szabó, Gábor, Terytze, Konstantin, Veres, Gábor, Weymann, Alexander   +17 more
core   +1 more source

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

Evaluation of a Decellularization Protocol for the Development of a Decellularized Tracheal Scaffold [PDF]

Anticancer Research, 2018
Currently, there are no effective solutions for the treatment of advanced disorders of the airways. The aim of this study was to assess the efficacy of a decellularization protocol of the trachea in order to produce a functional scaffold for serious clinical respiratory disorders.Rat tracheas were decellularized using a protocol which included ...
Dimou, Z., Michalopoulos, E., Katsimpoulas, M., Dimitroulis, D., Kouraklis, G., Stavropoulos-Giokas, C., Tomos, P.   +6 more
openaire   +3 more sources

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Optimization of Decellularization Procedure in Rat Esophagus for Possible Development of a Tissue Engineered Construct

Bioengineering, 2018
Background: Current esophageal treatment is associated with significant morbidity. The gold standard therapeutic strategies are stomach interposition or autografts derived from the jejunum and colon.
Panagiotis Mallis, Panagiota Chachlaki, Michalis Katsimpoulas, Catherine Stavropoulos-Giokas, Efstathios Michalopoulos   +4 more
doaj   +1 more source

Cell-derived decellularized extracellular matrices [PDF]

, 2018
The ability to create cell-derived decellularized matrices in a dish gives researchers the opportunity to possess a bioactive, biocompatible material made up of fibrillar proteins and other factors that recapitulates key features of the native structure and composition of in vivo microenvironments.
Greg M, Harris, Irene, Raitman, Jean E, Schwarzbauer   +2 more
openaire   +2 more sources

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

Partial decellularization eliminates immunogenicity in tracheal allografts

Bioengineering & Translational Medicine, 2023
There is currently no suitable autologous tissue to bridge large tracheal defects. As a result, no standard of care exists for long‐segment tracheal reconstruction.
Zheng Hong Tan, Lumei Liu, Sayali Dharmadhikari, Kimberly M. Shontz, Lily Kreber, Sarah Sperber, Jane Yu, Woo Yul Byun, Sarah C. Nyirjesy, Amy Manning, Susan D. Reynolds, Tendy Chiang   +11 more
doaj   +1 more source

Comparação de diferentes metodologias para descelularização de veias humanas [PDF]

, 2015
Introduction : Non-living tissues have shown to be an important source of biomaterials, with advantages such as hydrophilicity, low toxicicidade, low immunogenicity, in addition to good adherence and cell multiplication.
Oliveira, Madaí Cruz Lopes de
core  

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source