Results 71 to 80 of about 342,705 (245)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Development of a Patient Decision Aid on the Choice of Diabetes Medication for Filipino Patients with Type 2 Diabetes Mellitus

Journal of the ASEAN Federation of Endocrine Societies, 2019
Objective. To develop a locally adapted patient decision aid (PtDA) on treatment intensification among Filipino patients with Type 2 Diabetes Mellitus and to test the feasibility of using PtDAs in a low middle-income country. Methodology. A qualitative
Anna Angelica Macalalad-Josue, Lia Aileen Palileo-Villanueva, Mark Anthony Sandoval, Jose Paolo Panuda   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Design a decision-making aid: "alternative treatment for prostate cancer: what option do you prefer?"

Psicooncologia, 2010
Purpose: To design a Decision-making Aid within the ‘Benign Prostatic Hyperplasia’ healthcare process modelling of the Andalusian Public Health System (SSPA) for the therapeutic approach of early-stage disease.
Carmen Pérez, Enrique Alonso, Guadalupe Carmona, Araceli Caro, José Luis Padilla, Víctor Baena, Francisco J. Torrubia, María Josefa Requena, Ismael Herruzo, Ramón Linares, Reyes Sanz, José Luis Soler, Pedro Pablo Pérez, Juan Carlos Villalobos   +13 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Multicriteria Decision-aid [PDF]

Journal of the Operational Research Society, 1993
Alexis Tsoukias, Phillipe Vincke
  +4 more sources

‘This workshop was bright and beautiful’: insights into the process of co-production of images for decision aids with marginalised groups

Research for All
This co-production project worked with groups often marginalised in research, in order to improve the accessibility and inclusivity of two online patient decision aids through the use of images.
doaj   +2 more sources

Maintaining Accuracy While Reducing Effort in Online Decision Making: A New Quantitative Approach for Multi-Attribute Decision Problems Based on Principal Component Analysis

Journal of Theoretical and Applied Electronic Commerce Research
This paper explores consumer decision making, particularly focusing on the increasing prevalence of choices on the Internet such as online shopping. Examining the fundamental question of how individuals decide how to decide, our paper draws upon the ...
Herbert Jodlbauer, René Riedl
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Tempest in a Teapot – The Role of the Decision Tree in Enhancing Juror Comprehension and Whether It Interferes with the Jury’s Right to Deliberate Freely?

Oñati Socio-Legal Series, 2015
This article explores the potential of the decision tree (also referred to as a flow-chart, “Route to Verdict” or question-trail) to improve the legal comprehension of jurors in criminal trials. It examines why the decision tree has not yet been adopted
Marie Comiskey
doaj