Results 121 to 130 of about 193,992 (310)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Evolving prescribing practice through personalisation, the judicious use of decision aids, and clinical reasoning. [PDF]
Background Prescribing practice by nurses, pharmacists, and allied health professionals has progressed significantly over the past four decades and is expanding at an accelerated rate. My research questions, educational approaches, and written works stem
Gould, J.
core +1 more source
Application advances of decision aids in joint replacement patients
Huli yanjiu, 2020 This article reviewed the concept,theoretical framework, the forms of decision aids, and its application in joint replacement patients. It suggested that researches on decision aids for joint replacement in China were lack of evidence⁃based content and ...
GUO Yuru +8 more
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
AIDS/SAD Control Program Ministry of Health, Addis Ababa
, 2017 This report is published by the National AIDS Control Programme on a monthly basis. The major objectives of the publication are to:-Notify the current status of AIDS epidemic in the country, and provide information for decision making and future planning
AIDS/SAD Control Program
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Decision on the Progress Report on Aids Watch Africa (Awa) (Doc. Assembly/Au/6 (Vi)) [PDF]
, 2019 Progress Report and the AIDS Watch ...
The Assembly
core +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Relationship Between Poverty and HIV/AIDS in Rural Thailand
, 2007 HIV/AIDS is a global pandemic with critical demographic, economic, and social implications. The pandemic is widespread in poor regions of the world, including Southeast Asia where its long-term effects are potentially catastrophic.
Cameron, Michael Patrick
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