Journal of Cloud Computing: Advances, Systems and Applications, 2018 Cloud computing is a paradigm that provides services through the Internet. The paradigm has been influenced by previously available technologies (for example cluster, peer-to-peer, and grid computing) and has now been adopted by almost all large ...
Julian Araujo +5 more
doaj +1 more source
Big Data and Real-World Data based Cost-Effectiveness Studies and Decision-making Models: A Systematic Review and Analysis. [PDF]
Front Pharmacol, 2021 Lu ZK +5 more
europepmc +1 more source
And If Your Friends Jumped Off A Bridge, Would You Do It Too? : How Developmental Neuroscience Can Inform Legal Regimes Governing Adolescents [PDF]
, 2015 Legal models of adolescent autonomy and responsibility in various domains of law span a spectrum from categorical prohibitions of certain behaviors to recognitions of total adolescent autonomy.
Pustilnik, Amanda C, Tennison, Michael N
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Cargo Logistics Airlift Systems Study (CLASS). Volume 2: Case study approach and results [PDF]
Models of transportation mode decision making were developed. The user's view of the present and future air cargo systems is discussed. Issues summarized include: (1) organization of the distribution function; (2) mode choice decision making; (3) air ...
Burby, R. J., Kuhlman, W. H.
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Implications of integrating large language models into clinical decision making
Communications MedicineChristof & Armoundas explore how large language models (LLMs) can augment clinician-level clinical reasoning across the three pillars-framing the encounter, diagnostic reasoning, and treatment/management-highlighting gains in information synthesis and ...
Michael Christof, Antonis A. Armoundas
doaj +1 more source
Trustworthiness Evaluation of Large Language Models Using Multi-Criteria Decision Making
IEEE AccessAs Large language models (LLMs) become increasingly integrated into high-stakes applications, ensuring their trustworthiness has emerged as a critical research concern.
Meltem Aksoy +2 more
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AI bias: exploring discriminatory algorithmic decision-making models and the application of possible machine-centric solutions adapted from the pharmaceutical industry. [PDF]
AI Ethics, 2022 Belenguer L.
europepmc +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source