Results 31 to 40 of about 2,176,289 (311)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Decisions, Decisions, Decisions [PDF]

Journal of Electronic Resources Librarianship, 2002
ABSTRACT A case study of a Special Collections department in a small academic library and how its collections have been acquired and developed over the years is described. It looks at the changes that have occurred in the academic environment and what effect, if any, these changes may have had on the department and how it has adapted to them. It raises
  +4 more sources

Impact-based forecasting of tropical cyclone-related human displacement to support anticipatory action

Nature Communications
Tropical cyclones (TCs) displace millions every year. While TCs pose hardships and threaten lives, their negative impacts can be reduced by anticipatory actions like evacuation and humanitarian aid coordination.
Pui Man Kam, Fabio Ciccone, Chahan M. Kropf, Lukas Riedel, Christopher Fairless, David N. Bresch   +5 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

The role of direct air capture in achieving climate-neutral aviation

Nature Communications
Growing demand for air travel and limited scalable solutions pose significant challenges to the mitigation of aviation’s climate change impact. Direct air capture (DAC) may gain prominence due to its versatile applications for either carbon removal ...
Nicoletta Brazzola, Amir Meskaldji, Anthony Patt, Tim Tröndle, Christian Moretti   +4 more
doaj   +1 more source

Efficiency versus Equity in Spatial Siting of Electricity Generation: Citizen Preferences in a Serious Board Game in Switzerland

Energies, 2020
Energy transitions around the world will change the spatial fingerprint of the electricity sector, but there is a lack of studies on citizen preferences for siting the future mix of electricity technologies.
Franziska Steinberger, Tobias Minder, Evelina Trutnevyte   +2 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Climate-resilient strategy planning using the SWOT methodology: A case study of the Japanese wind energy sector

Climate Risk Management
As climate change leads to more frequent and intense extreme weather events, industry stakeholders and policymakers must assess their business strategies, practices, and entire sector policies under these uncertain conditions.
Lisa Bachmann, Ricarda Lex, Florian Regli, Saira Vögeli, Evelyn Mühlhofer, Jamie W. McCaughey, Susanne Hanger-Kopp, David N. Bresch, Chahan M. Kropf   +8 more
doaj   +1 more source

Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development

CPT: Pharmacometrics & Systems Pharmacology, 2019
Quantitative systems pharmacology (QSP), a mechanistically oriented form of drug and disease modeling, seeks to address a diverse set of problems in the discovery and development of therapies. These problems bring a considerable amount of variability and
Gabriel Helmlinger, Victor Sokolov, Kirill Peskov, Karen M. Hallow, Yuri Kosinsky, Veronika Voronova, Lulu Chu, Tatiana Yakovleva, Ivan Azarov, Daniel Kaschek, Artem Dolgun, Henning Schmidt, David W. Boulton, Robert C. Penland   +13 more
doaj   +1 more source