Results 41 to 50 of about 2,976,561 (304)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Climate-resilient strategy planning using the SWOT methodology: A case study of the Japanese wind energy sector

Climate Risk Management
As climate change leads to more frequent and intense extreme weather events, industry stakeholders and policymakers must assess their business strategies, practices, and entire sector policies under these uncertain conditions.
Lisa Bachmann, Ricarda Lex, Florian Regli, Saira Vögeli, Evelyn Mühlhofer, Jamie W. McCaughey, Susanne Hanger-Kopp, David N. Bresch, Chahan M. Kropf   +8 more
doaj   +1 more source

Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development

CPT: Pharmacometrics & Systems Pharmacology, 2019
Quantitative systems pharmacology (QSP), a mechanistically oriented form of drug and disease modeling, seeks to address a diverse set of problems in the discovery and development of therapies. These problems bring a considerable amount of variability and
Gabriel Helmlinger, Victor Sokolov, Kirill Peskov, Karen M. Hallow, Yuri Kosinsky, Veronika Voronova, Lulu Chu, Tatiana Yakovleva, Ivan Azarov, Daniel Kaschek, Artem Dolgun, Henning Schmidt, David W. Boulton, Robert C. Penland   +13 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Mangroves and their services are at risk from tropical cyclones and sea level rise under climate change

Communications Earth & Environment
Climate change is expected to alter the frequency and intensity of extreme events, modifying the natural disturbance regimes to which ecosystems are adapted.
Sarah Hülsen, Laura E. Dee, Chahan M. Kropf, Simona Meiler, David N. Bresch   +4 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Political flyer by Republicans for Responsible Decisions, calling for abortion to be taken off Republican Party Platform

This small yellow flyer was created by the group, Republicans for Responsible Decisions, to outline their position that the abortion issue should not be a central political issue within the Republican Party.
Republicans for Responsible Decisions
core   +3 more sources

Scaling court decisions with citation networks [PDF]

, 2023
To compare court decisions in a systematic way, it is typically necessary to first read these decisions and then apply legal methods to them. Measurement models that support analysts in this manual labor usually rely on judges’ voting records.
Gschwend, Thomas, Engst, Benjamin G., Thomas Gschwend, Benjamin G. Engst, Arnold, Christian; id_orcid, Arnold, Christian, Christian Arnold, Engst, Benjamin   +7 more
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Rebuilding Ukraine’s energy supply in a secure, economic, and decarbonised way

Environmental Research: Infrastructure and Sustainability
Since Russia’s 2022 invasion, Ukraine’s civilian energy infrastructure has faced systematic attack and requires urgent and strategic reconstruction.
Tim Tröndle, Olena Melnyk, Olena Tutova, Vira Porieva, Fabian Neumann, Iain Staffell, Anthony Patt   +6 more
doaj   +1 more source