Results 221 to 230 of about 18,940 (249)

Glomerular expression of biglycan and decorin and urinary levels of decorin in primary glomerular disease

Clinical Nephrology, 2004
Recent studies have suggested that small leucine-rich proteoglycans (SLRP) of the extracellular matrix play a major role in modulating the activity of growth factors and in regulating the deposition of collagens. In this study, the expression of the SLRPs biglycan and decorin in the glomeruli of patients with primary glomerular disease (minimal change ...
M, Kuroda, H, Sasamura, E, Kobayashi, R, Shimizu-Hirota, Y, Nakazato, M, Hayashi, T, Saruta   +6 more
openaire   +2 more sources

Downregulation of Decorin and Transforming Growth Factor-β1 by Decorin Gene Suppression in Tendinocytes

Connective Tissue Research, 2005
Scars formed after tendonitis result in altered tissue mechanical properties after injury. The interaction of collagen molecules with decorin affects collagen fibrogenesis, and scar tissue is fragile as a consequence of a large amount of decorin in the scar.
Yoshinao, Hosaka, Rikio, Kirisawa, Naoki, Mafune, Kazushige, Takehana   +3 more
openaire   +2 more sources

Structures of decorine and delcoridine

Chemistry of Natural Compounds, 1981
In order to confirm the structures of the alkaloids delcorine and delcoridine (O-demethyldelcorine) suggested previously, a direct passage has been performed from delcoridine to delcorine and from delcorine to delphatine. It has been shown that the α configuration of C1 - OCH3 previously suggested for delcorine and delcoridine is incorrect — it should ...
B. T. Salimov, M. G. Zhamierashvili, M. S. Yunusov   +2 more
openaire   +1 more source

Stimulated expression of decorin and the decorin gene in fibroblasts cultured from patients with localized scleroderma

Archives of Dermatological Research, 1995
Decorin mRNA levels, the content of decorin and the synthesis of dermatan sulphate in skin fibroblasts from patients with systemic and localized scleroderma were investigated. Approximately a 2.2-fold increase in decorin mRNA levels, was found by Northern blot analysis in localized scleroderma, but no significant changes were found in systemic ...
T, Izumi, S, Tajima, T, Nishikawa
openaire   +2 more sources

Decorin counteracts disease progression in mice with recessive dystrophic epidermolysis bullosa.

Matrix Biology, 2019
Loss-of-function mutations in the gene encoding type VII collagen underlie recessive dystrophic epidermolysis bullosa (RDEB), a disease characterized by skin and mucosal blistering, impaired wound healing, and diffuse dermal inflammation and fibrosis ...
F. Cianfarani, Emanuela De Domenico, A. Nyström, S. Mastroeni, D. Abeni, E. Baldini, S. Ulisse, P. Uva, L. Bruckner-Tuderman, G. Zambruno, D. Castiglia, T. Odorisio   +11 more
semanticscholar   +1 more source

Decorin expression in quiescent myogenic cells

Biochemical and Biophysical Research Communications, 2008
Satellite cells are quiescent muscle stem cells that promote postnatal muscle growth and repair. When satellite cells are activated by myotrauma, they proliferate, migrate, differentiate, and ultimately fuse to existing myofibers. The remainder of these cells do not differentiate, but instead return to quiescence and remain in a quiescent state until ...
Takanori, Nishimura, Kenjiro, Nozu, Yasuhiro, Kishioka, Jun-Ichi, Wakamatsu, Akihito, Hattori   +4 more
openaire   +2 more sources

Ageing-associated endothelial decorin induction and the impact of non-glycanated decorin on cardiac inflammation

Cardiovascular Research
Abstract Aims Cardiovascular disease is the leading cause of death in the European Union and ageing is one of its major risk factors resulting in the progressive deterioration of the cardiac structures and function.
Guillermo Luxán, Timm Winkelmeier, Colin Bodemer, Büşra Nur Toğru, Mariana Shumliakivska, Marion Muhly-Reinholz, Ariane Fischer, Mariano Ruz Jurado, David John, Wesley T Abplanalp, Stefanie Dimmeler   +10 more
openaire   +2 more sources

A role for decorin in the remodeling of myocardial infarction

Matrix Biology, 2005
Because the small leucine-rich proteoglycan decorin has been implicated in regulation of collagen fibrillogenesis leading to proper extracellular matrix assembly, we hypothesized it could play a key role in cardiac fibrosis following myocardial infarction.
Sara M, Weis, Scott D, Zimmerman, Maithili, Shah, James W, Covell, Jeffrey H, Omens, John, Ross, Nancy, Dalton, Ying, Jones, Charles C, Reed, Renato V, Iozzo, Andrew D, McCulloch   +10 more
openaire   +2 more sources

Decorin in the spatial control of collagen mineralization

Materials Horizons
Both COL I and pCOL I fibrils undergo nonhierarchical and hierarchical intrafibrillar mineralization in the PLIP system, respectively. However, DCN disrupts the mineralization process, indicating the inhibition of DCN in collagen mineralization.
Yuming Bai, Peng Wu, Qiufang Zhang, Feng Lin, Ling Hu, Zhisheng Zhang, Wenxia Huang, Yin Xiao, Qiliang Zuo   +8 more
openaire   +5 more sources

Structural Change in Decorin with Skin Aging

Connective Tissue Research, 2006
Decorin, the main proteoglycan in skin, has a small size with a core protein of approximately 40kDa and one chondroitin sulfate/dermatan sulfate glycosaminoglycan (GAG) chain. The main function of decorin is to regulate the collagen matrix assembly. Decorin is distributed along collagen fibrils with the core protein and the decorin GAG chain controls ...
openaire   +2 more sources