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Decorin in the Tumor Microenvironment.
Advances in Experimental Medicine and Biology, 2020The tumor microenvironment plays a determining role in cancer development through a plethora of interactions between the extracellular matrix and tumor cells. Decorin is a prototype member of the SLRP family found in a variety of tissues and is expressed in the stroma of various forms of cancer. Decorin has gained recognition for its essential roles in
Kornélia Baghy +3 more
semanticscholar +3 more sources
Selective inactivity of TGF-β/decorin complexes [PDF]
FEBS Letters, 1994 Previous studies had shown that binding of TGF-β to the small proteoglycan decorin results in its inactivation. Indeed, in osteosarcoma cells the addition of decorin prevented the TGF-β1-mediated up-regulation of biglycan synthesis.
Andrej Hasilík +2 more
exaly +2 more sources
Decorin mediated biomimetic PCL-gelatin nano-framework to impede scarring.
International Journal of Biological Macromolecules, 2022Scars occur as a result of fibrosis after tissue damage or surgery and reports suggest that excessive Transforming growth factor-β (TGF-β) activity during the process of wound healing leads to progressive fibrosis. Decorin is an extracellular matrix (ECM)
A. Vijayan +6 more
semanticscholar +1 more source
Biosynthesis of decorin and glypican
Matrix Biology, 2000Decorin and glypican are two examples of exclusively chondroitin/dermatan sulfate and heparan sulfate-substituted proteoglycans, respectively. Decorin is a secretory product, whereas glypican is linked to membrane lipids via a glycosyl-phosphatidyl-inositol (GPI) anchor.
L A, Fransson +5 more
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Effect of Exogenous Decorin on Cell Morphology and Attachment of Decorin-Deficient Fibroblasts
Journal of Biochemistry, 1996We have reported deficient expression of decorin on skin fibroblasts from a patient with carbohydrate-deficient glycoprotein syndrome type I [Gu, J. and Wada, Y. (1995) J. Biochem. 117, 1276-1279]. The characteristics of fibroblasts from this patient included increased cell spreading and reduced proliferation.
J, Gu, Y, Wada
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Reconstruction of glycosaminoglycan chains in decorin
Biochemical and Biophysical Research Communications, 2002The glycosaminoglycan chain of decorin from human spinal ligaments was digested using the hydrolysis of bovine testicular hyaluronidase. As a result, decorin with hexasaccharide, octasaccharide, and decasaccharide including the linkage region, GlcA-Gal-Gal-Xyl, was obtained.
Mito, Iwafune +6 more
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Differential interactions of decorin and decorin mutants with type I and type VI collagens
FEBS Journal, 2004The small leucine‐rich proteoglycan decorin can bind via its core protein to different types of collagens such as type I and type VI. To test whether decorin can act as a bridging molecule between these collagens, the binding properties of wild‐type decorin, two full‐length decorin species with single amino acid substitutions (DCN E180K, DCN E180Q ...
Gordon, Nareyeck +5 more
exaly +3 more sources
Small Leucine Rich Proteoglycans (decorin, biglycan and lumican) in cancer.
Clinica chimica acta; international journal of clinical chemistry, 2019The extracellular matrix (ECM) prevents invasion of tumour cells and possesses an intrinsic mechanism to down-regulate signalling processes that promote cancer proliferation. Small Leucine Rich Proteoglycans (SLRPs) are ubiquitous ECM components involved
Sandeep Appunni +5 more
semanticscholar +1 more source