Results 171 to 180 of about 18,918 (210)

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation. [PDF]

Nat Immunol
Theobald H, Bejarano DA, Katzmarski N, Haub J, Schulte-Schrepping J, Yu J, Bassler K, Ament AL, Osei-Sarpong C, Piattini F, Vornholz L, T'Jonck W, Györfi AH, Hayer H, Yu X, Sheoran S, Al Jawazneh A, Chakarov S, Haendler K, Brown GD, Williams DL, Bosurgi L, Distler JHW, Ginhoux F, Ruland J, Beyer MD, Greter M, Bain CC, Vazquez-Armendariz AI, Kopf M, Schultze JL, Schlitzer A.   +31 more
europepmc   +1 more source

The role of dectin-1 in health and disease

Immunobiology, 2021
Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). This CLR identifies ligands independently of Ca2+ and is majorly involved in coupling of innate with adaptive immunity. Formerly, Dectin-1 was best known for
Namarta Kalia, Jatinder Singh, Manpreet Kaur   +2 more
exaly   +3 more sources

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Emerging roles of Dectin-1 in noninfectious settings and in the CNS

Trends in Immunology, 2021
Dectin-1 is a C-type lectin receptor (CLR) expressed on the surface of various mammalian myeloid cells. Dectin-1 recognizes β-glucans and elicits antifungal proinflammatory immune responses. Recent studies have begun to examine the biology of Dectin-1 in previously less explored settings, such as homeostasis, sterile inflammation, and in the central ...
M Elizabeth Deerhake, Mari L Shinohara
exaly   +3 more sources

A critical role of Dectin-1 in hypersensitivity pneumonitis

Inflammation Research, 2015
Hypersensitivity pneumonitis (HP) is a pulmonary disease caused by repeated exposure to various aspiration antigens, including bacteria and fungi. Although TLRs are known to be required for the generation of HP triggered by bacteria, the significance of fungal receptors remains unclear. The present study aimed to investigate whether Dectin-1 and Dectin-
Toshiki Yabe-Wada, Takashi Mochizuki, Koichi Makimura   +2 more
exaly   +3 more sources

Arabinoxylan activates Dectin‐1 and modulates particulate β‐glucan‐induced Dectin‐1 activation

Molecular Nutrition & Food Research, 2015
ScopeArabinoxylan is one of the most commonly consumed dietary fiber. Immunomodulation by arabinoxylan is documented but the mechanisms by which these immune‐effects are accomplished are unknown.Methods and resultsBy applying reporter cell lines for Toll‐like receptors (TLRs) and Dectin‐1, we demonstrated that arabinoxylan interacts with Dectin‐1 ...
Sahasrabudhe, Neha M., Schols, Henk A., Faas, Marijke M., de Vos, Paul   +3 more
openaire   +3 more sources

Dectin-1 escape by fungal dimorphism

Trends in Immunology, 2005
Candida albicans, a medically important fungus, exists primarily as yeast and filamentous forms. Its cell wall is rich in beta-glucans, which are recognized by a lectin-like innate immune receptor, Dectin-1. A recent study shows that exposure of glucan, by yeasts but not filaments, determines Dectin-1-dependent uptake by macrophages, and thus ...
Heinsbroek, Sigrid E. M., Brown, Gordon D., Gordon, Siamon   +2 more
openaire   +3 more sources

The Role of Dectin-1 in Antifungal Immunity

Critical Reviews in Immunology, 2004
beta-Glucans are structural components of fungal cell walls, which have a stimulatory effect on the immune system. Although a number of receptors for these carbohydrates have been proposed, the recently identified C-type lectin-like receptor, Dectin-1, appears to play a central role.
Jurgen, Herre, Janet A, Willment, Siamon, Gordon, Gordon D, Brown   +3 more
openaire   +2 more sources

β‐Glucans and Dectin‐1

Annals of the New York Academy of Sciences, 2008
β‐Glucans are naturally occurring carbohydrates that possess immune‐modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of β‐glucan receptors, such as dectin‐1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates.
S. Vicky Tsoni, Gordon D. Brown
openaire   +1 more source

Fungal Recognition by TLR2 and Dectin-1

2008
The innate immune system utilizes multiple receptors to recognize fungal pathogens, and the net inflammatory response is controlled by interactions between these receptors. Many fungi are recognized, at least in part, by Toll-like receptor 2 (TLR2) and Dectin-1.
Helen S, Goodridge, David M, Underhill
openaire   +2 more sources

The Biological Role of Dectin-1 in Immune Response

International Reviews of Immunology, 2007
The identification of antigen-recognizing receptors in the innate immune system significantly helped us to understand the initiation and regulation of the innate immune response. Dectin-1 was recently identified as the most important receptor for beta-glucan.
Lina, Sun, Yong, Zhao
openaire   +2 more sources