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Pilz-Beta-Glukane aktivieren die Immunantwort über verschiedene Rezeptoren, darunter C-Typ-Lektin-Rezeptoren (CLRs). Eine besondere Rolle spielt dabei Dectin-1. Frühere Studien deuteten darauf hin, dass der Dectin-1-Signalweg, der zur Interleukinproduktion führt, nur durch Hefepartikel aktiviert werden konnte, indem eine Immunsynapse gebildet wird. Die
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Dectin-1 limits allergic responses
Science, 2018Allergy Aberrant activation of pattern recognition receptors (PRRs) drives inflammation in autoimmune and allergic diseases. Gour et al. identified invertebrate tropomyosin from house dust mites and shrimp as a ligand for dectin-1. Dectin-1 is a PRR that recognizes fungal β-glucans in antifungal immune responses.
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Dectin-1 Acts as a Non-Classical Receptor of Ang II to Induce Cardiac Remodeling
Circulation Research, 2023He Huang, Yang Ye, Weijian Huang
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Dectin-1 Signaling Update: New Perspectives for Trained Immunity
Frontiers in Immunology, 2022Carlos Del Fresno
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Particulate β‐glucans synergistically activate TLR4 and Dectin‐1 in human dendritic cells
Molecular Nutrition and Food Research, 2016Neha M Sahasrabudhe, Paul De Vos
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