Results 181 to 190 of about 18,918 (210)
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Molecular and functional characterization of human Dectin-1
Experimental Hematology, 2002Dendritic cells (DC) have several unique features that differ from other antigen-presenting cells and that enable them to initiate primary immune responses. The aim of this study was to identify and characterize genes that are differentially expressed in DC generated from CD14+ peripheral blood monocytes in vitro.Using a subtractive cDNA library, we ...
Frank, Grünebach +3 more
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Roles of Dectin-1 in Allergic Airway Inflammation
Critical Reviews in Immunology, 2017Asthma is a chronic allergic inflammatory disease of the airways. The symptoms can be controlled by inhaled corticosteroids together with long-acting β2 agonists in the majority of patients; however, in some patients, their symptoms remain uncontrolled even under intensive treatment.
Koichi, Hirose +2 more
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Increased expression of dectin-1 in nasal polyps
American Journal of Otolaryngology, 2013A fungal etiology has been proposed to underlie severe nasal polyps (NP). Dectin-1 is an innate immune pattern recognition receptor which is involved in the recognition of some pathogenic fungi. We investigated the Dectin-1 levels in NP in order to evaluate the implication of such expression with respect to the development of NP.Normal inferior ...
Jian, Gong +3 more
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2012
Natural killer (NK) cell receptors belong to two unrelated, but functionally analogous gene families: the immunoglobulin superfamily, situated in the leukocyte receptor complex (LRC) and the C-type lectin receptors (CLRs) superfamily, located in the natural killer gene complex (NKC). Wong et al.
Rajesh K. Gupta, G. S. Gupta
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Natural killer (NK) cell receptors belong to two unrelated, but functionally analogous gene families: the immunoglobulin superfamily, situated in the leukocyte receptor complex (LRC) and the C-type lectin receptors (CLRs) superfamily, located in the natural killer gene complex (NKC). Wong et al.
Rajesh K. Gupta, G. S. Gupta
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The Core Fucose on an IgG Antibody is an Endogenous Ligand of Dectin‐1
Angewandte Chemie - International Edition, 2019 AbstractThe core fucose, a major modification of N‐glycans, is implicated in immune regulation, such as the attenuation of the antibody‐dependent cell‐mediated cytotoxicity of antibody drugs and the inhibition of anti‐tumor responses via the promotion of PD‐1 expression on T cells.
Yoshiyuki Manabe +2 more
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Annals of the New York Academy of Sciences, 2009
beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates.
S Vicky, Tsoni, Gordon D, Brown
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beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates.
S Vicky, Tsoni, Gordon D, Brown
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Identification of the Porcine C-type lectin dectin-1
Veterinary Immunology and Immunopathology, 2009Beta-glucans are conserved glucose polymers found in the cell walls of plants, fungi, yeasts and bacteria. They have a backbone of beta-(1-3)-linked glucose units with beta-(1-6)-glucan-linkages. Although a number of receptors are thought to play a role in mediating the biological response to beta-glucans, dectin-1, a C-type lectin, was described as ...
Eva, Sonck +3 more
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Variation in the Yak Dectin-1 Gene ( CLEC7A )
DNA and Cell Biology, 2011C-type lectin domain family 7, member A (CLEC7A, dectin-1) plays an important role in antifungal immunity and belongs to the family of C-type lectin receptors. Variation in the extended exon 4-6 region of the yak dectin-1 gene (CLEC7A), which encodes the β-glucan recognition domain, was investigated using polymerase chain reaction-single strand ...
Guo, Yang +4 more
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Dectin-1: unique appetite for yeast
Blood, 2004Comment on Herre et al, page [4038][1] Dectin-1 is a myeloid receptor involved in phagocytosis of fungal pathogens that uses a unique mechanism of internalization and cellular signaling. P hagocytosis of pathogens is a critically important activity of cells of the innate immune system.
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Dectin-1 (CLEC7A, BGR, CLECSF12)
2016Dectin-1 is the archetypical example of the C-type lectin receptor (CLR) family of pattern recognition receptors (PRRs). Expressed primarily by cells of the innate immune system, this receptor is best known for its role in antifungal immunity through its ability to recognise cell wall β-glucans.
Patawee Asamaphan +2 more
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