Results 131 to 140 of about 22,245,271 (149)

Glabridin Inhibits Aspergillus fumigatus Growth and Alleviate Inflammation Mediated by Dectin-2 and NLRP3 Inflammasome

Current Eye Research, 2023
Purpose The research was used to uncover the mechanism of glabridin in Aspergillus fumigatus keratitis in anti-fungus and anti-inflammation. Methods In vitro, RAW 264.7 cells were infected with A.
Lu Zhan, Xue Tian, Jing Lin, Xudong Peng, Guiqiu Zhao   +4 more
semanticscholar   +1 more source

Abstract 2964: Targeting tumor-associated macrophages to enhance anti-tumor immunity with the Dectin-2 agonistic antibody BDC-3042

Cancer Research, 2023
Tumor-associated macrophages (TAMs) are the largest immune cell population in many cancers and play a key role in establishing the immunosuppressive tumor microenvironment (TME) that enables tumor progression.
Justin A. Kenkel, Fang Xiao, P. Ho, J. Nolin, Rishali K. Gadkari, Laughing Bear Torrez, David T. Omstead, Katelynn A. McEachin, J. Ptacek, Rachel Grgich, C. Pearson, Stefan Chun, Cindy L. Kreder, Karla A. Henning, Han K. Kim, Lu Xu, S. Chapin, Michael N. Alonso, Shelley E. Ackerman   +18 more
semanticscholar   +1 more source

Identification and gene expression of bovine C-type lectin dectin-2

Veterinary Immunology and Immunopathology, 2006
The C-type lectin receptor has been shown to recognize carbohydrate moieties of self and non-self antigens, thus serving as an innate immune receptor. Using bioinformatics and molecular cloning techniques, we isolated a bovine gene that encodes a polypeptide of 206 amino acids with structural features shared by mouse and human dectin-2, including a ...
M, Bonkobara, M, Hoshino, H, Yagihara, K, Tamura, M, Isotani, Y, Tanaka, T, Washizu, K, Ariizumi   +7 more
openaire   +2 more sources

Abstract CT154: BDC-3042, a first-in-class Dectin-2 agonist, in patients with advanced malignancies: Results from the first-in-human dose-escalation study

Cancer Research
Dectin-2 is an immune-activating pattern recognition receptor that promotes immune responses against various microbial pathogens. Dectin-2 is expressed by myeloid cells including tumor-associated macrophages (TAMs), which are generally thought to ...
E. Dumbrava, Ildefonso Ismael Rodriguez, M. Salkeni, Antonio Giordano, Chris Chen, Sheena Sahota, Edith A. Perez, Tai Yu, Katherine Rosenthal, K. Balacy, Danlin Cai, J. Ptacek, Lu Xu, Dawn E. Colburn, Shelley E. Ackerman, Michael N. Alonso, Justin A. Kenkel, A. Vandross   +17 more
semanticscholar   +1 more source

Dectin-2 in Antimicrobial Immunity and Homeostasis

2016
Dendritic cell-associated lectin-2 (Dectin-2) is one of the most well-characterized members of the C-type lectin family. Recent studies have revealed its indispensable functions as a pattern recognition receptor (PRR) for a wide variety of pathogens, including fungi, bacteria, and viruses.
Rikio Yabe, Shinobu Saijo
openaire   +1 more source

Abstract 2883: Dectin-2 agonist antibodies reprogram tumor-associated macrophages to drive anti-tumor immunity

Cancer Research, 2022
Tumor-associated macrophages (TAMs), an abundant immune cell population in most cancers, support tumor progression through their immunosuppressive effects.
Justin A. Kenkel, P. Ho, Karla A. Henning, Cindy L. Kreder, J. Nolin, S. Kongara, S. Chapin, A. Husain, M. Kowanetz, E. Engleman, Michael N. Alonso, D. Dornan, Shelley E. Ackerman   +12 more
semanticscholar   +1 more source

Dendritic Cell Lectin Receptors (Dectin-2 Receptors Family)

2012
Dendritic cells (DCs) are special subsets of antigen presenting cells characterized by their potent capacity to activate immunologically naive T cells to induce initial immune responses. DCs are far more potent than macrophages and B cells in their capacity to activate immunologically naive T cells.
Rajesh K. Gupta, G. S. Gupta
openaire   +1 more source

Distinct roles for Dectin-1 and Dectin-2 in skin wound healing and neutrophilic inflammatory responses.

Journal of Investigative Dermatology, 2020
C-type lectin receptors (CLRs) recognize microbial polysaccharides. The CLRs Dectin-1 and Dectin-2, which are triggered by β-glucan and α-mannan, respectively, contribute to up-regulation of the inflammatory response.
Kenji Yamaguchi, E. Kanno, H. Tanno, Ayako Sasaki, Yuki Kitai, T. Miura, Naoyuki Takagi, Miki Shoji, J. Kasamatsu, Ko Sato, Yuka Sato, Momoko Niiyama, Y. Goto, K. Ishii, Y. Imai, S. Saijo, Y. Iwakura, M. Tachi, K. Kawakami   +18 more
semanticscholar   +1 more source

Induction of CD8+ T cell responses through targeting of antigen to Dectin-2

Cellular Immunology, 2006
Targeted delivery of antigens to dendritic cells (DC) can be used to optimise immunisation. We investigated whether the efficacy with which immune responses are induced can be improved by targeting Ags to a C-type lectin receptor, Dectin-2. When anti-Dectin-2 mAbs were injected s.c., mAb binding was detected on a low percentage of DC in the draining ...
Robert W, Carter, Clare, Thompson, Delyth M, Reid, Simon Y C, Wong, David F, Tough   +4 more
openaire   +2 more sources

A phase 1/2 study of BDC-3042, a novel dectin-2 agonistic antibody, in patients with advanced cancers.

Journal of Clinical Oncology
TPS2695 Background: Tumor-associated macrophages (TAMs) are a major component of the immune infiltrate in most cancers and play a key role in establishing the immunosuppressive tumor microenvironment (TME) that enables tumor progression.
M. Salkeni, A. Vandross, E. Dumbrava, Antonio Giordano, Chris Chen, Justin A. Kenkel, Danlin Cai, Lu Xu, Michael N. Alonso, Shelley E. Ackerman, Tai Yu, Dawn E. Colburn, Edith A. Perez, Sharon Wilks   +13 more
semanticscholar   +1 more source