Results 111 to 120 of about 12,249 (194)

C-type lectin-like receptors of the dectin-1 cluster : ligands and signaling pathways [PDF]

, 2013
Peer reviewedPublisher ...
Brown, Gordon D, Plato, Anthony, Willment, Janet A   +2 more
core   +1 more source

Why, Immunologically, Housing‐Related Fungi and Endotoxins (and Other Chronic Pro‐Inflammatory Stressors) Risk Latent Tuberculosis Reactivation, Severe Asthma, and Translocating and Invasive Infections in Indigenous Communities in Canada

American Journal of Human Biology, Volume 38, Issue 4, April 2026.
ABSTRACT Type 1/M1/TH1 and type 3/M1/TH17 pro‐inflammatory switches are risks for latent Mycobacterium tuberculosis (Mtb) reactivation and ongoing infection transmission. This paper considers the heavy toll of reactivation risk in Indigenous communities in Canada and the chronic, everyday pro‐inflammatory stressors connected with type 3/M1/TH17 immune ...
Stacie Burke
wiley   +1 more source

Signalling C-Type lectin receptors, microbial recognition and immunity [PDF]

, 2014
This work was supported in part by the Wellcome Trust, Medical Research Council (UK) and the University of Cape Town. J.C. Hoving is a Carnegie Corporation postdoctoral researcher at the University of Cape Town.
Brown, Gordon D, Hoving, J. Claire, Watson, Gillian J.   +2 more
core   +1 more source

Glial cytokine modulation improves sleep and circadian disruption in female SAA knock‐in mice of Alzheimer's‐related pathology

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Sleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear. METHODS We longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPPSAA knock‐in and control mice from 2 to 19 months using ...
Teresa Macheda, Margaret R. Hawkins, Carrie E. Johnson, Madison G. Lapid, Haleigh R. Whitlock, Savannah M. Shepard, MaKayla F. Cox, Kelly N. Roberts, Leke Bytyqi, Heather M. Hash, Omar A Abou El‐Ezz, Mohammed Abou El‐Ezz, Katherina Kohler, Sridhar Sunderam, Bruce F. O'Hara, Linda J. Van Eldik, Michael P. Murphy, Marilyn J. Duncan, Adam D. Bachstetter   +18 more
wiley   +1 more source

Lactate signalling regulates fungal β-glucan masking and immune evasion [PDF]

, 2016
AJPB: This work was supported by the European Research Council (STRIFE, ERC- 2009-AdG-249793), The UK Medical Research Council (MR/M026663/1), the UK Biotechnology and Biological Research Council (BB/K017365/1), the Wellcome Trust (080088; 097377).
A Hopke, B Ferwerda, BN Gantner, C Kuei, CA Johnston, CA Munro, CA Rappleye, CJ Barelle, CJ Heilmann, DH Owen, DO Inglis, E Leberer, FN Gravelat, G Bindea, GD Brown, GJ Sosinska, HJ Flint, I Jacobs, ID Iliev, IV Ene, IV Ene, IV Ene, IV Ene, JE Nett, JM Bain, K Lemaire, LE Lewis, LM Graham, M Galán-Díez, M Karababa, M Santos, MG Netea, MG Netea, MJ Marakalala, MM Maidan, MT Kelly, N Vieira, NAR Gow, P Shannon, PR Desai, RA Hall, RT Wheeler, RT Wheeler, RT Wheeler, S Lev, S Shahana, SdJ Carrion, SE Hardison, SM Noble, TR O'Meara, YL Chen   +50 more
core   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, Volume 2, Issue 2, April 2026.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

A novel mechanism for binding of galactose-terminated glycans by the C-type carbohydrate recognition domain in blood dendritic cell antigen 2 [PDF]

, 2015
Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these cells, but the natural ligands for the ...
Drickamer, K, Dungarwalla, T, Feinberg, H, Jégouzo, SAF, Taylor, ME, Weis, WI   +5 more
core   +1 more source

Molecular Cloning of Human Dectin-2 [PDF]

Journal of Investigative Dermatology, 2004
Kanazawa, Nobuo, Tashiro, Kei, Inaba, Kayo, Lutz, Manfred B., Miyachi, Yoshiki   +4 more
openaire   +2 more sources

Cellular metabolism constrains innate immune responses in early human ontogeny [PDF]

, 2018
Pathogen immune responses are profoundly attenuated in fetuses and premature infants, yet the mechanisms underlying this developmental immaturity remain unclear.
A Prosser, AA Sharma, AA Sharma, AC Panda, Axel Olin, B Everts, B Kan, B Novakovic, BN Gantner, C Genomes Project, C Michalski, CB Wilson, CC Thoreen, CE Delsing, CM Shen, Collaborators GBDCM., DS Bundschuh, E Jong de, E Lachmandas, EA Marchant, EL Pearce, EO Glocker, G Bindea, G Majai, GD Brown, GD Brown, Heather R. Conti, J Dominguez-Andres, J Leentjens, JW Yu, KG Destin, L Liu, M Azizia, MA Bouhlel, Mathieu Nadeau-Vallee, Matthew S. Kelly, ME Ritchie, MF Princiotta, MG Netea, MG Netea, MG Netea, MG Netea, ML Gil, MN Corradetti, NA Gow, O Gross, O Larsson, P Shannon, Pierre Tissières, PM Lavoie, PR Taylor, R Elfakess, S Altmeier, S Arandjelovic, SC Cheng, SE Turvey, SI Gringhuis, SS Schuller, T Strunk, T Weichhart, TR Kollmann, VM Kamp, VT Vachharajani, WKE Ip, X Su   +64 more
core   +2 more sources

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection [PDF]

, 2015
Aspergillus fumigatus forms ubiquitous airborne conidia that humans inhale on a daily basis. Although respiratory fungal infection activates the adaptor proteins CARD9 and MyD88 via C-type lectin, Toll-like, and interleukin-1 family receptor signals ...
Cramer, RA, Heung, LJ, Hohl, TM, Jhingran, A, Junecko, BAF, Kasahara, S, Kazmierczak, BI, Knoblaugh, SE, Kumasaka, DK, Lin, X, Reinhart, TA, Shepardson, KM   +11 more
core   +1 more source