Results 31 to 40 of about 202,692 (284)
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
, 1995 Collage of Congresswoman Elizabeth Furse at the Community Action building dedication in 1995.[front] October 20, 1995; Thank you Elizabeth for making this day more special for all!!; Community Action in Washington ...
core +1 more source
Bulletin du Centre de Recherche du Château de Versailles, 2021 The first edition of Filippo Paruta’s La Sicilia descritta con medaglie (Palermo, 1612) was a bibliographical rarity which was in Mazarin’s library thanks to Cardinal Francesco Barberini.
Yvan Loskoutoff
doaj +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Electronic Notes in Theoretical Computer Science, 1997 AbstractWe dedicate this Proceedings of MFPS XIII to Dana S. Scott on the occasion of his 65th birthday. During the meeting, a special session focused on the many and varied contributions of Dana's work to semantics and related areas. On behalf of the participants at MFPS XIII, the Organizers wish to express their thanks and their admiration to Dana ...
openaire +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Gender and generation gaps in government organization: does it affect work engagement?
Jurnal Siasat Bisnis, 2021 Purpose: This research proposed to evaluate the differences between generations and gender work engagement. This evaluation is strategically needed to clarify the debate related to the issue of work engagement.
Gugup Kismono +1 more
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source