Results 91 to 100 of about 35,686 (231)

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma

Cancers
Simple Summary Liposarcoma is a rare cancer of adipose tissue with limited treatment options. Here, we studied the fuel used by liposarcoma to develop a new strategy for treatment.
Kyle D. Klingbeil, Blake R. Wilde, D. Graham, Serena Y. Lofftus, Tyler R. McCaw, N. Matulionis, Sarah M. Dry, Joseph G. Crompton, F. Eilber, Thomas G. Graeber, D. Shackelford, H. Christofk, B. Kadera   +12 more
semanticscholar   +1 more source

Selinexor versus doxorubicin in dedifferentiated liposarcoma PDXs: evidence of greater activity and apoptotic response dependent on p53 nuclear accumulation and survivin down‐regulation

Journal of experimental & clinical cancer research : CR, 2021
Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53.
V. Zuco, S. Pasquali, M. Tortoreto, S. Brich, Stefano Percio, G. Dagrada, C. Colombo, R. Sanfilippo, C. Lauricella, M. Gounder, R. El Bezawy, M. Barisella, A. D. Dei Tos, P. Casali, A. Gronchi, S. Stacchiotti, N. Zaffaroni   +16 more
semanticscholar   +1 more source

Expression of the preadipocyte marker ZFP423 is dysregulated between well-differentiated and dedifferentiated liposarcoma

BMC Cancer, 2022
Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential.
Thanh N. Dang, R. P. Tiongco, Loren M. Brown, Jessica L. Taylor, J. Lyons, F. Lau, Z. Floyd   +6 more
semanticscholar   +1 more source

Not all NTRK fusions in mesenchymal neoplasia are driver events: implications on classification and targeted therapy

The Journal of Pathology: Clinical Research, Volume 12, Issue 5, September 2026.
Abstract NTRK fusions drive the pathogenesis of a distinctive group of mesenchymal neoplasms with significant impact on classification and targeted therapy. However, unexpected NTRK fusions have been reported in other sarcoma entities, raising uncertainty over their specificity and clinical management.
Mohamed A Yakoub, Purvil Sukhadia, Carla Saoud, Meera Hameed, Cristina R Antonescu   +4 more
wiley   +1 more source

A rare case of para-testicular dedifferentiated liposarcoma: a diagnostic dilemma [PDF]

, 2023
Paratesticular dedifferentiated liposarcoma (DD-LPS) are rare neoplasms. It has been estimated that 12% of DD-LPS occur in the paratesticular region, while the retroperitoneum is the most common site for this tumor.
Patel, Himanshu U., Modi, Biren P.
core   +1 more source

Dedifferentiated liposarcoma with heterologous spindle cell rhabdomyoblastic de-differentiation: An unusual pattern expanding the morphological spectrum

Indian Journal of Pathology and Microbiology, 2020
Dedifferentiated liposarcoma (DDLS) is characterized by a wide histopathological spectrum. Spindle cell type of rhabdomyoblastic dedifferentiation has been rarely described in case of DDLS.
Bharat Rekhi, Akshay D Baheti, Shraddha Patkar   +2 more
doaj   +1 more source

Intra‐Abdominal Myxoid Leiomyosarcoma With PLAG1 Gene Rearrangement Following Prior Laparoscopic Myomectomy: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT PLAG1 immunohistochemistry and FISH were essential for diagnosis of extra‐uterine myxoid leiomyosarcoma and should be considered in myxoid intra‐abdominal tumors, especially in patients with previous uterine surgery.
Cheng‐En Hsieh, Po‐Hsuan Wu, Chang‐Wei Su, Yu‐Chun Ma, Hsuan‐Ying Huang   +4 more
wiley   +1 more source

Case report: Paratesticular dedifferentiated liposarcoma with poor prognosis

Frontiers in Oncology, 2022
Background/Aim Most paratesticular liposarcomas (PLPSs) are well-differentiated liposarcomas (WDLPSs) with favourable prognoses. As such, the rare occurrence of PLPS often leads to its misdiagnosis as a hernia or hydrocele on physical examination ...
H. Suto, Y. Inui, A. Okamura
semanticscholar   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source