Results 71 to 80 of about 35,686 (231)

CD4+ T cell and M2 macrophage infiltration predict dedifferentiated liposarcoma patient outcomes

Journal for ImmunoTherapy of Cancer, 2021
Background Dedifferentiated liposarcoma (DDLPS) is one of the most common soft tissue sarcoma subtypes and is devastating in the advanced/metastatic stage. Despite the observation of clinical responses to PD-1 inhibitors, little is known about the immune
B. Schroeder, N. LaFranzo, B. LaFleur, R. Gittelman, M. Vignali, Shi-Hong Zhang, K. Flanagan, J. Rytlewski, Laura Riolobos, B. Schulte, Teresa S. Kim, E. Chen, K. Smythe, M. Wagner, J. Mantilla, J. Campbell, R. Pierce, Robin L. Jones, L. Cranmer, S. Pollack   +19 more
semanticscholar   +1 more source

Chloroquine Combined With Rapamycin Arrests Tumor Growth in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Dedifferentiated Liposarcoma

In Vivo, 2022
Background/Aim: Dedifferentiated liposarcoma (DDLS) is a type of soft-tissue sarcoma with a poor prognosis due to distant metastasis and resistance to chemotherapy. The antimalarial drug chloroquine (CQ) can induce apoptosis in cancer cells.
Noriyuki Masaki, Y. Aoki, Y. Kubota, K. Obara, J. Miyazaki, R. Hoffman   +5 more
semanticscholar   +1 more source

Dedifferentiated Liposarcoma Mimicking a Primary Colon Mass

, 2017
Dedifferentiated liposarcoma is typically a nonlipogenic high-grade sarcoma that arises from well-differentiated liposarcoma. It most commonly presents as a large mass in the retroperitoneum.
Laura W. Lamps, George W. English, Roopa Ram, Jason S. Mizell, Jerad M. Gardner, Blake Hollowoa, Julia A. Bridge   +6 more
core   +1 more source

Diagnosis and management of dedifferentiated liposarcoma: A multidisciplinary position statement.

Cancer Treatment Reviews
Dedifferentiated liposarcoma (DDLPS) is a malignant mesenchymal neoplasm in desperate need of novel therapeutic approaches. Often occurring in conjunction with well-differentiated liposarcoma (WDLPS), DDLPS can behave more aggressively and exhibits a ...
C. Haddox, J. Hornick, C. Roland, Elizabeth H Baldini, Vicki L. Keedy, R. Riedel   +5 more
semanticscholar   +1 more source

First‐line chemotherapy in advanced intra‐abdominal well‐differentiated/dedifferentiated liposarcoma: An EORTC Soft Tissue and Bone Sarcoma Group retrospective analysis

Cancer, 2022
No prospective trial with anthracycline‐based chemotherapy has individually assessed response in a well‐differentiated (WD)/dedifferentiated (DD) liposarcoma patient cohort.
S. Stacchiotti, W. V. D. van der Graaf, R. Sanfilippo, S. Marréaud, W. V. van Houdt, I. Judson, A. Gronchi, H. Gelderblom, S. Litière, B. Kasper   +9 more
semanticscholar   +1 more source

Routine MDM2 FISH Testing and Preoperative Biopsy Reduces Recurrence Rate of Atypical Lipomatous Tumours

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Although MDM2 FISH test has been increasingly used to differentiate ALT and benign lipomatous tumours, its impact on clinical outcome remains underexplored. This study investigated whether routine MDM2 FISH testing on preoperative biopsy is associated with a reduction in the recurrence risk of ALT.
Samuel O. H. Ching, Anderson S. M. Leung, Raymond C. H. Yau, Albert Y. L. Lam, Tony W. H. Shek, Maximus C. F. Yeung   +5 more
wiley   +1 more source

Role of CDK4 as prognostic biomarker in Soft Tissue Sarcoma and synergistic effect of its inhibition in dedifferentiated liposarcoma sequential treatment

Experimental Hematology & Oncology
Soft tissue sarcomas represent an heterogeneous group of rare mesenchymal tumors comprising 1% of all solid malignancies. Among them, liposarcoma is one of the most common histotypes with atypical lipomatous tumor/well differentiated liposarcoma and ...
S. Vanni, G. Miserocchi, Graziana Gallo, V. Fausti, S. Gabellone, C. Liverani, C. Spadazzi, C. Cocchi, Chiara Calabrese, G. De Luca, Massimo Bassi, M. Gessaroli, Nicolà Tomasetti, A. Campobassi, F. Pieri, G. Ercolani, Davide Cavaliere, L. Gurrieri, N. Riva, F. Recine, Toni Ibrahim, L. Mercatali, Robin L. Jones, A. De Vita   +23 more
semanticscholar   +1 more source

Comparison of three-dimensional cell culture techniques of dedifferentiated liposarcoma and their integration with future research

Frontiers in Cell and Developmental Biology
Background: Dedifferentiated liposarcoma is a formidable sarcoma subtype due to its high local recurrence rate and resistance to medical treatment.
Sayumi Tahara, Soumya Sharma, F. C. D. de Faria, Patricia Sarchet, L. Tomasello, Sydney Rentsch, Roma Karna, Federica Calore, Raphael E. Pollock   +8 more
semanticscholar   +1 more source

A case of dedifferentiated liposarcoma showing a biphasic pattern on 2-deoxy-2-F18- fluoro-D-glucose positron emission tomography/ computed tomography

Rare Tumors, 2013
Integrated 2-deoxy-2-F18-fluoro-D-glucose positron emission tomography combined with computed tomography (FDG-PET/CT) has been used in the field of soft tissue sarcoma.
Manabu Hoshi, Naoto Oebisu, Jun Takada, Hiroaki Nakamura, Kenichi Wakasa   +4 more
doaj   +1 more source

Intraoperative Evaluation of Sarcoma Surgical Margins With Indocyanine Green Fluorescence Imaging: Results From an Observational Study

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction Sarcomas are rare malignancies that affect both adults and children. Surgical removal with negative histopathological margins is the foundation of sarcoma treatment. Failure to achieve negative margins puts patients at risk of local recurrence (LR). LR rates range between 10% and 30%.
Sumail Bhogal, Matthew Gong, William Li, Brenda Diergaarde, Alma Heyl, Clark Roth, Lawrence Garvin II, Alexander Hoffman, Amanda Locker, Ines Lohse, Maria Silvaggio, Stella Lee, Richard McGough, Kurt Weiss   +13 more
wiley   +1 more source