Results 31 to 40 of about 22,113 (265)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
IdeguruThe ability to solve problems in math and confidence are two crucial skills that need to be built in math learning in the 21st century. However, many students have a challenge in understanding concepts in depth and applying them to solve problems.
Rusmini Rusmini +5 more
doaj +1 more source
How to Get Rid of the Belief Bias: Boosting Analytical Thinking via Pragmatics
Europe's Journal of Psychology, 2019 The previous research attempts to reduce the influence of the belief bias on deductive thinking have often been unsuccessful and, when they succeeded, they failed to replicate. In this paper, we propose a new way to see an old problem.
Laura Macchi +5 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
A deduction from Dirac sea model [PDF]
Physics Essays, 2016 10 pages, 1 figure, published in Physics Essays 29(2), 218 (2016)
Bian, Jianguo, Wang, Jiahui
openaire +2 more sources
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
Journal of Advanced Mechanical Design, Systems, and ManufacturingSimulation-based optimization often requires many simulations and can be difficult to adapt due to time constraints. To solve this problem, constructing approximators for simulations, such as the finite element method using machine learning, has ...
Yoshiharu IWATA, Hidefumi WAKAMATSU
doaj +1 more source
JUPITER, HERCULES AND HERMES: REFLECTIONS ON THE DISCRETIONARY BOND INTERPRETIVE EACH
Revista Eletrônica de Direito Processual, 2020 The goal to be achieved in the first instance is to make some reflections on the mythological models judge, brought by François Ost in your text Jupiter, Hercules y Hermes: three models juez, and their levels of discretion in their decisions.
Victor Saldanha Priebe +1 more
doaj +1 more source