Results 41 to 50 of about 202,857 (337)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Developing Inductive–Deductive Models with Cognitive Conflict to Enhance Students Problem-Solving and Confidence

Ideguru
The ability to solve problems in math and confidence are two crucial skills that need to be built in math learning in the 21st century. However, many students have a challenge in understanding concepts in depth and applying them to solve problems.
Rusmini Rusmini, Dian Armanto, Mukhtar Mukhtar, Nuraini Sribina, Muhammad Rizky Mazaly, Muhammad Rizky Mazaly   +5 more
doaj   +1 more source

Philosophy and the practice of Bayesian statistics [PDF]

, 2010
A substantial school in the philosophy of science identifies Bayesian inference with inductive inference and even rationality as such, and seems to be strengthened by the rise and practical success of Bayesian statistics.
Abbott, Ashby, Atkinson, Barkow, Bartlett, Bayarri, Bayarri, Bayarri, Berger, Berk, Berk, Bernardo, Binmore, Bousquet, Box, Box, Box, Braithwaite, Brown, Cesa-Bianchi, Claeskens, Cox, Cox, Cox, Cox, Csiszár, Dawid, Donovan, Doob, Earman, Eggertsson, Fitelson, Foster, Fraser, Freedman, Gelman, Gelman, Gelman, Gelman, Gelman, Gelman, Gelman, Gelman, Gelman, Gelman, Gelman, Gelman, Gelman, Ghitza, Ghosh, Giere, Gigerenzer, Gigerenzer, Glymour, Good, Good, Gray, Greenland, Greenland, Grünwald, Grünwald, Gustafson, Guttorp, Haack, Hacking, Halpern, Hastie, Hempel, Hill, Hjort, Holland, Howson, Hunter, Jaynes, Kass, Kass, Kass, Kelly, Kelly, Kitcher, Kleijn, Kolakowski, Kuhn, Kuhn, Lakatos, Laudan, Laudan, Li, Lijoi, Lindsay, Manski, Manski, Mayo, Mayo, Mayo, Mayo, McAllister, McCarty, Merrill, Metropolis, Morris, Müller, Newman, Norton, Paninski, Popper, Quine, Raftery, Ripley, Rivers, Robins, Rubin, Rubin, Russell, Salmon, Savage, Schervish, Seidenfeld, Seidenfeld, Shalizi, Snijders, Spanos, Stove, Stove, Tilly, Tilly, Toulmin, Tukey, Uffink, Uffink, Vansteelandt, Vidyasagar, Vuong, Wahba, Wasserman, Weinberg, White, Wooldridge, Ziman   +138 more
core   +5 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

An Abstract Approach to Consequence Relations

, 2019
We generalise the Blok-J\'onsson account of structural consequence relations, later developed by Galatos, Tsinakis and other authors, in such a way as to naturally accommodate multiset consequence.
Cintula, Petr, Férez, José Gil, Moraschini, Tommaso, Paoli, Francesco   +3 more
core   +1 more source

Who is a theorist? [PDF]

, 2011
This article carefully analyzes a recent paper by Weisberg in which it is claimed that when Mendeleev discovered the periodic table he was not working as a modeler but instead as a theorist.
Scerri, Eric
core   +5 more sources

A deduction from Dirac sea model [PDF]

Physics Essays, 2016
10 pages, 1 figure, published in Physics Essays 29(2), 218 (2016)
Bian, Jianguo, Wang, Jiahui
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Confirmation of driving principle by weight analysis of Integration Neural Network and extension of deductive approximator

Journal of Advanced Mechanical Design, Systems, and Manufacturing
Simulation-based optimization often requires many simulations and can be difficult to adapt due to time constraints. To solve this problem, constructing approximators for simulations, such as the finite element method using machine learning, has ...
Yoshiharu IWATA, Hidefumi WAKAMATSU
doaj   +1 more source

JUPITER, HERCULES AND HERMES: REFLECTIONS ON THE DISCRETIONARY BOND INTERPRETIVE EACH

Revista Eletrônica de Direito Processual, 2020
The goal to be achieved in the first instance is to make some reflections on the mythological models judge, brought by François Ost in your text Jupiter, Hercules y Hermes: three models juez, and their levels of discretion in their decisions.
Victor Saldanha Priebe, Fabiana Marion Spengler   +1 more
doaj   +1 more source