Results 51 to 60 of about 526,100 (292)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Simulations of deep pencil-beam redshift surveys [PDF]

Monthly Notices of the Royal Astronomical Society, 2001
We create mock pencil-beam redshift surveys from very large cosmological $N$-body simulations of two Cold Dark Matter cosmogonies, an Einstein-de Sitter model ($τ$CDM) and a flat model with $Ω_0 =0.3$ and a cosmological constant ($Λ$CDM). We use these to assess the significance of the apparent periodicity discovered by Broadhurst et al.
Yoshida, N., Colberg, Jorg M., White, S. D. M. (Simon D. M.), Evrard, August E., MacFarland, T. J., Couchman, H. M. P., Jenkins, A. R., Frenk, C. S., Pearce, Frazer R., Efstathiou, G., Peacock, J. A., Thomas, P. A.   +11 more
openaire   +4 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Influence of Multiple Openings on Reinforced Concrete Outrigger Walls in a Tall Building

Applied Sciences, 2019
Outrigger systems have been used to control the lateral displacement of tall buildings. Reinforced concrete (R.C.) outrigger walls with openings can be used to replace conventional steel outrigger trusses.
Han-Soo Kim, Yi-Tao Huang, Hui-Jing Jin
doaj   +1 more source

Strengthening Solutions for Deep Reinforced Concrete Beam with Cutout Opening

Buildings, 2021
Since reinforced concrete (RC) buildings have long service life, cutout openings are generally needed in their load-bearing walls as a sustainable solution in order to meet new requirements of their users.
Alireza Bahrami, Felicia Ågren, Kim Kollberg   +2 more
doaj   +1 more source

Deep Inelastic Scattering with the SPS Muon Beam [PDF]

International Journal of Modern Physics A, 2015
We review results from deep inelastic muon scattering experiments at the SPS which started in 1978, and are still actively pursued today. Key results include the precision measurement of scaling violations and of the strong coupling constant, spin-dependent structure functions, and studies of the internal spin structure of protons and neutrons.
Mallot, Gerhard K., Voss, Rüdiger
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Modification of strut effectiveness factor for reinforced concrete deep beams strengthened with CFRP laminates

Materiales de Construccion, 2014
This paper proposes a method to modify the strut effectiveness factor in the strut-and-tie model for CFRP-strengthened reinforced concrete deep beams.
M. Panjehpour, A. A. A. Ali, Y. L. Voo, F. N. Aznieta   +3 more
doaj   +1 more source