Results 111 to 120 of about 691,118 (406)

Subthalamic Nucleus Deep Brain Stimulation Modulates 2 Distinct Neurocircuits

Annals of Neurology, 2020
Current understanding of the neuromodulatory effects of deep brain stimulation (DBS) on large‐scale brain networks remains elusive, largely due to the lack of techniques that can reveal DBS‐induced activity at the whole‐brain level.
Lunhao Shen, Changqing Jiang, C. S. Hubbard, Jianxun Ren, Changgeng He, Danhong Wang, L. Dahmani, Yi Guo, Yiming Liu, Shujun Xu, F. Meng, Jianguo Zhang, Hesheng Liu, Luming Li   +13 more
semanticscholar   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Neurofeedback-enabled beta power control with a fully implanted DBS system in patients with Parkinson's disease [PDF]

OBJECTIVE: Parkinsonian motor symptoms are linked to pathologically increased beta oscillations in the basal ganglia. Studies with externalised deep brain stimulation electrodes showed that Parkinson patients were able to rapidly gain control over these ...
Baumann, Christian R, Bichsel, Oliver, Bujan, Bartosz, Gassert, Roger, Imbach, Lukas L, Jedrysiak, Piotr, Oertel, Markus F, Rohr-Fukuma, Manabu, Salzmann, Lena, Stieglitz, Lennart H   +9 more
core   +1 more source

Neurosurgery for psychopaths? The problems of empathy and neurodiversity [PDF]

, 2016
I argue that deep brain stimulation (DBS) is a bad approach for incarcerated psychopaths for two reasons. First, given what we know about psychopathy, empathy, and DBS, it is unlikely to function as an effective treatment for the moral problems that ...
Ramirez, Erick
core   +1 more source

Deep Brain Stimulation Programming for Movement Disorders: Current Concepts and Evidence-Based Strategies

Frontiers in Neurology, 2019
Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of Parkinson's disease, medically intractable essential tremor, and complicated segmental and generalized dystonia.
T. Koeglsperger, Carla Palleis, F. Hell, J. Mehrkens, K. Bötzel   +4 more
semanticscholar   +1 more source

Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms

Nature Communications, 2020
Deep brain stimulation (DBS) of the subthalamic nucleus is a symptomatic treatment of Parkinson’s disease but benefits only to a minority of patients due to stringent eligibility criteria.
S. Valverde, Marie Vandecasteele, Charlotte Piette, Willy Derousseaux, G. Gangarossa, Asier Aristieta Arbelaiz, J. Touboul, B. Degos, L. Venance   +8 more
semanticscholar   +1 more source

Stimulation of zona incerta selectively modulates pain in humans

Scientific Reports, 2021
Stimulation of zona incerta in rodent models has been shown to modulate behavioral reactions to noxious stimuli. Sensory changes observed in Parkinsonian patients with subthalamic deep brain stimulation suggest that this effect is translatable to humans.
Charles W. Lu, Daniel E. Harper, Asra Askari, Matthew S. Willsey, Philip P. Vu, Andrew D. Schrepf, Steven E. Harte, Parag G. Patil   +7 more
doaj   +1 more source

A functional micro-electrode mapping of ventral thalamus in Essential Tremor [PDF]

, 2018
Deep brain stimulation enables the delivery of therapeutic interventions to otherwise inaccessible areas of the brain while, at the same time, offering the unique opportunity to record from these same regions in awake patients.
Brittain, John-Stuart, Brown, Peter, Cagnan, Hayriye, Pedrosa, David J., Timmermann, Lars, Visser-Vandewalle, Veerle, Wirths, Jochen   +6 more
core   +1 more source

Adaptive deep brain stimulation for Parkinson’s disease using motor cortex sensing

Journal of Neural Engineering, 2018
Objective. Contemporary deep brain stimulation (DBS) for Parkinson’s disease is delivered continuously, and adjustments based on patient’s changing symptoms must be made manually by a trained clinician.
Nicole C. Swann, C. de Hemptinne, Margaret C. Thompson, S. Miocinovic, Andrew M. Miller, Ro’ee Gilron, J. Ostrem, H. Chizeck, P. Starr   +8 more
semanticscholar   +1 more source

A Multi-rater Comparative Study of Automatic Target Localization Methods for Epilepsy Deep Brain Stimulation Procedures [PDF]

arXiv, 2022
Epilepsy is the fourth most common neurological disorder and affects people of all ages worldwide. Deep Brain Stimulation (DBS) has emerged as an alternative treatment option when anti-epileptic drugs or resective surgery cannot lead to satisfactory outcomes.
arxiv