Results 61 to 70 of about 121,878 (259)

Deep brain stimulation of the brainstem

Brain, 2020
Abstract Deep brain stimulation (DBS) of the subthalamic nucleus, pallidum, and thalamus is an established therapy for various movement disorders. Limbic targets have also been increasingly explored for their application to neuropsychiatric and cognitive disorders.
Gavin J B Elias, Aaron Loh, Dave Gwun, Aditya Pancholi, Alexandre Boutet, Clemens Neudorfer, Jürgen Germann, Andrew Namasivayam, Robert Gramer, Michelle Paff, Andres M Lozano   +10 more
openaire   +3 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Early Experiences with Robotic-assisted Implantation of Deep Brain Stimulation Electrodes in Awake or Asleep Patients in Japan

Neurologia Medico-Chirurgica
This study evaluated 14 patients who underwent robot-assisted deep brain stimulation electrode implantation and described our early experiences and workflows in both awake and asleep states.
Masafumi FUKUDA, Yosuke ITO, Tomoyoshi OTA, Hiroshi MASUDA, Makoto OISHI   +4 more
doaj   +1 more source

IncobotulinumtoxinA and Deep Brain Stimulation [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2019
ABSTRACT:Guidelines recommend Botulinum toxin-A (BoNT-A) after deep brain stimulation (DBS), although the effectiveness of their combined use is uncertain. A chart review of Parkinson’s disease (17) and dystonia (7) patients undergoing 302 injections with IncobotulinumtoxinA before or after DBS was performed.
Derrick, Soh, Alfonso, Fasano
openaire   +2 more sources

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Single-cell transcriptome analysis reveals mechanisms by which hippocampal deep brain stimulation promotes neurorepair and microglial subpopulation remodeling in ischemic stroke

Journal of Translational Medicine
Background In patients with ischemic stroke, the hippocampus is one of the most severely damaged regions of the brain; however, the optimal parameters for hippocampal deep brain stimulation in these patients remain unknown.
Xuyu Zhao, Yiyang Cao, Xiao Li, Peiru Wu, Jianxin Zhou, Qing Zou, Huanle Hong, Jingying Huang, Rabia Sultan, Jiao Wang   +9 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Deep brain stimulation of posterior hypothalamic area for cluster headache

Cephalalgia Reports, 2018
Background: Deep brain stimulation of the posterior hypothalamic area is one of the neuromodulation treatments used for chronic cluster headache, but the number of published patients remains low.
Antti Huotarinen, Mikko Kallela, Ville Artto, Aki Laakso, Riku Kivisaari   +4 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source