Results 41 to 50 of about 4,865,431 (261)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Structural and functional topography of the anterior limb of the internal capsule in treatment-resistant psychiatric disorders

Deep Brain Stimulation
The anterior limb of the internal capsule (ALIC) is a major target for deep brain stimulation (DBS) in obsessive-compulsive disorder and other treatment-resistant psychiatric disorders.
Reem El Jammal, Hideo Suzuki, Layth S. Mattar, Thomas Hamre, Sarah Soubra, Melissa A. Ryan, Raissa K. Mathura, Sanjay J. Mathew, Anusha Allawala, Eric A. Storch, Nora Vanegas Arroyave, Garrett P. Banks, Nader Pouratian, Remi Patriat, Wayne K. Goodman, Nicole R. Provenza, Sameer A. Sheth, Eleonora Bartoli, Sarah R. Heilbronner   +18 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Long-Term Efficacy and Safety of Chronic Globus Pallidus Internus Stimulation in Different Types of Primary Dystonia [PDF]

, 2009
Background: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) offers a very promising therapy for medically intractable dystonia. However, little is known about the long-term benefit and safety of this procedure. We therefore performed a
Voges, J., Steude, U., Zeitler, K., Sturm, V., Bötzel, Kai, Mehrkens, Jan Hinnerk, Schnitzler, A.   +6 more
core   +1 more source

Contribution of animal models to DBS research in movement and psychiatric disorders: A review

Deep Brain Stimulation
Deep brain stimulation (DBS) has evolved through a dynamic interplay between clinical and pre-clinical research. Initially inspired by invasive clinical practices such as ablations, resections, and other lesion-based interventions, minimally-invasive ...
David Dominguez-Paredes, Berkhan Genc, Yasin Temel, Ali Jahanshahi   +3 more
doaj   +1 more source

The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders

Biomedicines, 2021
Anxiety and depression exhibit high comorbidity and share the alteration of the amygdala–hippocampal–prefrontal network, playing different roles in the ventral and dorsal hippocampi.
Hanna Vila-Merkle, Alicia González-Martínez, Rut Campos-Jiménez, Joana Martínez-Ricós, Vicent Teruel-Martí, Arantxa Blasco-Serra, Ana Lloret, Pau Celada, Ana Cervera-Ferri   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Functional MRI with active, fully implanted, deep brain stimulation systems: Safety and experimental confounds [PDF]

, 2007
We investigated safety issues and potential experimental confounds when performing functional magnetic resonance imaging (fMRI) investigations in human subjects with fully implanted, active, deep brain stimulation (DBS) systems.
Lemieux, L., Thornton, John, Yousry, Tarek, Thobois, S., Pinto, Serge, Allen, P.J., Lemieux, Louis, Carmichael, David, Limousin-Dowsey, Patricia, Pinto, S., Limousin-Dowsey, P., Thornton, J.S., Thobois, Stéphane, Carmichael, D.W., Yousry, T., Allen, Philip   +15 more
core  

Rehabilitation based on brain-computer interface for aphasic patients: A systematic review

Deep Brain Stimulation
Aphasia is the disturbance of language production and/or comprehension. From 25–40 % of patients with stroke manifest aphasia. Although many rehabilitation techniques are known, a large percentage of these patients do not recover language function.
Massimiliano Domenico Rizzaro, Luigi Gianmaria Remore, Valeria Lo Faso, Giorgio Fiore, Luigi Schisano, Elena Pirola, Antonella Ampollini, Giulio Andrea Bertani, Stefania Elena Navone, Giovanni Marfia, Marco Locatelli   +10 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source