Results 101 to 110 of about 5,284,179 (294)

A Multi‐Scale Computational Framework for Evaluating Wireless Neuromodulation Feasibility via Magnetoelectric Nanoparticles

Advanced Science, EarlyView.
A multiscale computational framework links single‐nanoparticle magnetoelectric behavior to tissue‐level electric field distributions, integrating experimental data from nanoparticle characterization and in vitro stimulation setups. Applied to a cortical slice configuration, the framework predicts optimal MENP concentrations and stimulation parameters ...
Marta Bonato, Elric Zhang, Emma Chiaramello, Serena Fiocchi, Giulia Suarato, Valentin Gantenbein, Nathalia Cancino‐Fuentes, Alejandro Suarez‐Perez, Maria V. Sanchez‐Vives, Salvador Pané, Marta Parazzini   +10 more
wiley   +1 more source

Computational Investigation of Adaptive Deep Brain Stimulation

, 2015
Deep Brain Stimulation of the sub-thalamic nucleus (STN) has been proven to be effective at reducing symptoms of patients with Parkinson's disease (PD).
Thang, CY, Paul A. Meehan, Meehan, PA, Christopher Y. Thang   +3 more
core   +1 more source

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors

Advanced Science, EarlyView.
Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici, Mike Bismuth, Meir Goldsmith, Dan Peer, Tali Ilovitsh   +4 more
wiley   +1 more source

Septal stimulation attenuates hippocampal seizure with subregion specificity

Epilepsia Open
Objective Deep brain stimulation (DBS) is a promising approach for the treatment of epilepsy. However, the optimal target for DBS and underlying mechanisms are still not clear.
Qingyang Zhang, Yu Wang, Fei Wang, Dongxiao Jiang, Yingjie Song, Lin Yang, Mengdi Zhang, Yi Wang, Yeping Ruan, Jiajia Fang, Fan Fei   +10 more
doaj   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Development of a miniature device for emerging deep brain stimulation paradigms.

PLoS ONE, 2019
Deep brain stimulation (DBS) is a neuromodulatory approach for treatment of several neurological and psychiatric disorders. A new focus on optimising the waveforms used for stimulation is emerging regarding the mechanism of DBS treatment.
Scott D Adams, Kevin E Bennet, Susannah J Tye, Michael Berk, Abbas Z Kouzani   +4 more
doaj   +1 more source

Advance on treatment of major depression with deep brain stimulation

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
About 1/3 of patients with major depression cannot benefit from regular antidepressant therapy, psychotherapy and cognitive behavioral treatment (CBT). Currently, deep brain stimulation (DBS), as a new treatment, has been used to treat major depression ...
Zhi-qiang CUI, Zhi-pei LING
doaj   +1 more source

Τhe multiple temporalities of deep brain stimulation (DBS) in Greece

Medicine, Health Care and Philosophy, 2018
This contribution intends to explore patients' lived experience, with a focus on the temporal dimension. On the basis of a qualitative study that led me to interview persons with Parkinson's disease (PD), caregivers, and medical professionals, I develop an empirical and philosophical investigation of the temporalities surrounding the implementation of ...
openaire   +3 more sources