Results 91 to 100 of about 5,284,179 (294)

Test-retest reliability of resting-state functional magnetic resonance imaging during deep brain stimulation for Parkinson’s disease

NeuroImage: Clinical
Background: Patients implanted with modern deep brain stimulation (DBS) hardware can now undergo functional magnetic resonance imaging (fMRI), leading to its increased used to study DBS’ mechanisms and predict optimal therapy settings.
Skyler Deutsch, Juhi Mehta, Lee B. Reid, Andrea Fuentes, Sarah Wang, John Kornak, Philip A. Starr, Jill L. Ostrem, Doris D. Wang, Ian O. Bledsoe, Melanie A. Morrison   +10 more
doaj   +1 more source

Long-Term Effect of GPi-DBS in a Patient With Generalized Dystonia Due to GLUT1 Deficiency Syndrome

Frontiers in Neurology, 2018
Treatment outcomes from pallidal deep brain stimulation are highly heterogeneous reflecting the phenotypic and etiologic spectrum of dystonia. Treatment stratification to neurostimulation therapy primarily relies on the phenotypic motor presentation ...
Idil Hanci, Idil Hanci, Idil Hanci, Christoph Kamm, Marlieke Scholten, Marlieke Scholten, Marlieke Scholten, Marlieke Scholten, Lorenzo P. Roncoroni, Lorenzo P. Roncoroni, Lorenzo P. Roncoroni, Yvonne Weber, Yvonne Weber, Rejko Krüger, Rejko Krüger, Rejko Krüger, Rejko Krüger, Christian Plewnia, Christian Plewnia, Alireza Gharabaghi, Alireza Gharabaghi, Daniel Weiss, Daniel Weiss, Daniel Weiss   +23 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Safety of transcranial direct current stimulation in a patient with deep brain stimulation electrodes

Arquivos de Neuro-Psiquiatria
Background: Transcranial direct current stimulation (tDCS) has been investigated in movement disorders, making it a therapeutic alternative in clinical settings.
Aline Iannone, Nasser Allam, Joaquim P. Brasil-Neto   +2 more
doaj   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Low frequency deep brain stimulation in the inferior colliculus ameliorates haloperidol-induced catalepsy and reduces anxiety in rats.

PLoS ONE, 2020
Deep brain stimulation (DBS) of the colliculus inferior (IC) improves haloperidol-induced catalepsy and induces paradoxal kinesia in rats. Since the IC is part of the brain aversive system, DBS of this structure has long been related to aversive behavior
Hannah Ihme, Rainer K W Schwarting, Liana Melo-Thomas   +2 more
doaj   +1 more source

Special Issue: Trends in Clinical Deep Brain Stimulation

, 2021
Deep brain stimulation (DBS) has been successfully applied in several neurological and psychiatric disorders [...
Yasin Temel, Marcus L. F. Janssen, Janssen, M.L.F.; id_orcid, Temel, Y.   +3 more
core   +1 more source

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Standardized wireless deep brain stimulation system for mice

npj Parkinson's Disease
Deep brain stimulation (DBS) has emerged as a revolutionary technique for accessing and modulating brain circuits. DBS is used to treat dysfunctional neuronal circuits in neurological and psychiatric disorders.
Alexander Grotemeyer, Tobias Petschner, Robert Peach, Dirk Hoehl, Torsten Knauer, Uwe Thomas, Heinz Endres, Robert Blum, Michael Sendtner, Jens Volkmann, Chi Wang Ip   +10 more
doaj   +1 more source