Results 81 to 90 of about 5,284,179 (294)

Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease [PDF]

, 2015
Background Patients with advanced Parkinson's disease (PD) often present with axial symptoms, including postural- and gait difficulties that respond poorly to dopaminergic agents.
Pienaar, Ilse, De Paola, V, Gretenkord, Sabine, David Dexter (3572210), Sabine Gretenkord, Withers, Dominic, Ilse Pienaar (4504357), Dominic Withers (3572216), Gartside, Sarah, De Paola, Vincenzo, Puneet Sharma, Ilse S. Pienaar, Puneet Sharma (3572222), Sharma, Puneet, Dominic Withers, Sabine Gretenkord (3572213), David T. Dexter, Vincenzo De Paola, Joanna L. Elson, Ilse Pienaar (3572219), Joanna L Elson (16036517), Sarah Gartside (3572225), Dexter, David, Elson, Joanna, Sarah E. Gartside, Joanna Elson (271089), Vincenzo De Paola (275215), Sarah E Gartside (16264538), David T Dexter (9237410)   +28 more
core   +1 more source

Photonic‐Enabled Energy‐Efficient Transparent Neuromorphic Computing Devices: A Review

Advanced Science, EarlyView.
Transparent photonic neuromorphic computing devices merge optics and brain‐inspired computing to overcome von Neumann bottlenecks with ultrafast, low‐energy processing. By exploiting transparent oxides, 2D materials, phase‐change materials, and hybrid heterostructures, these platforms enable photonic synapses, memory, and logic for see‐through edge ...
Shuvaraj Ghosh, Ki‐bum Lee, Junghyeon Lee, Seunghee Cho, Malkeshkumar Patel, Hangfei Li, Yu Wen, Ye Zhou, Joondong Kim   +8 more
wiley   +1 more source

Efficacy and safety of deep brain stimulation in mesencephalic locomotor region for motor function in patients with post-stroke hemiplegia: a study protocol for a multi-center double-blind crossover randomized controlled trial

Frontiers in Neurology
BackgroundDeep brain stimulation (DBS) is a potential treatment for improving movement disorder. However, few large-sample studies can reveal its efficacy and safety.
Junpeng Xu, Junpeng Xu, Bin Liu, Bin Liu, Shuzhen Liu, Zhebin Feng, Zhebin Feng, Yanyang Zhang, Di Liu, Qing Chang, Haonan Yang, Haonan Yang, Yuhan Chen, Xinguang Yu, Zhiqi Mao   +14 more
doaj   +1 more source

Deep Brain Stimulation with 7 Tesla MRI - Improving Accuracy, Maximising Benefits

, 2022
Ultra-high field 7 Tesla (7T) MRI offers potential for improving accuracy and maximising the benefits of Deep Brain Stimulation (DBS). We propose a novel study design to test the utility of 7T MRI data in deep brain stimulation by testing how this data ...
Michael Hart
core   +1 more source

Retinomorphic Visual Processing Enabled by Contact‐Engineered IGZO Optoelectronic Synaptic Memtransistors

Advanced Science, EarlyView.
Here, we present an optoelectronic synaptic memtransistor (OSMT) integrating photoresponsive IGZO with contact‐engineered HfO2, enabling electrically and optically tunable synaptic weights. The device demonstrates broad range of tunable conductance states and array‐level image processing, highlighting its potential for intelligent machine vision ...
Donghyun Kang, San Nam, Dayul Nam, In‐Soo Kim, Myung‐Gil Kim, Sung Kyu Park, Yong‐Hoon Kim   +6 more
wiley   +1 more source

Selecting the Most Effective DBS Contact in Essential Tremor Patients Based on Individual Tractography

Brain Sciences, 2020
Postoperative choice of the most effective deep brain stimulation (DBS) contact in patients with essential tremor (ET) so far relies on lengthy clinical testing.
Jan Niklas Petry-Schmelzer, Till A. Dembek, Julia K. Steffen, Hannah Jergas, Haidar S. Dafsari, Gereon R. Fink, Veerle Visser-Vandewalle, Michael T. Barbe   +7 more
doaj   +1 more source

The Influence of Deep Brain Stimulation Intensity and Duration on Symptoms Evolution in an OFF Stimulation Dystonia Study

, 2013
Background: Deep brain stimulation (DBS) of the internal globus pallidus (GPi) is an established therapy for primary generalized dystonia. However, the evolution of dystonia symptoms after DBS discontinuation after years of therapy has only rarely been ...
Ruge, Diane, Limousin, Patricia, Gonzalez, Victoria, Vasques, Xavier, Cif, Laura, Hariz, Marwan I.,, Coubes, Philippe, Rothwell, John   +7 more
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Model diagram BMT = best medical therapy; DBS = Deep brain stimulation.

, 2016
Model diagram BMT = best medical therapy; DBS = Deep brain stimulation.
Adrian C. Williams (1305264), Alexander L. Green (320544), W. M. Michael Schuepbach (3148794), Tomasz Fundament (3148782), Paul R. Eldridge (3148785), Rod S. Taylor (3148791), Alan L. Whone (3148788)   +6 more
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source