Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Deep brain stimulation in idiopathic Parkinson’s disease
Northwestern Medical Journal, 2023 Parkinson’s disease (PD) is the second most common neurodegenerative and progressive neurological disorder characterized by tremors, rigidity, bradykinesia, and postural instability.
Canan Akünal Türel, Murat Arıcan
doaj +1 more source
Communication impairments in Parkinson's disease [PDF]
, 2011 published_or_final_versio
Murdoch, Bruce +3 more
core +3 more sources
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
An evaluation of neuroplasticity and behavior after deep brain stimulation of the nucleus accumbens in an animal model of depression. [PDF]
, 2011 BACKGROUND: Recent interest has demonstrated the nucleus accumbens (NAcc) as a potential target for the treatment of depression with deep brain stimulation (DBS).
Falowski, Steven M +5 more
core +2 more sources
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Effect of neurostimulation on cognition and mood in refractory epilepsy. [PDF]
, 2018 Epilepsy is a common, debilitating neurological disorder characterized by recurrent seizures. Mood disorders and cognitive deficits are common comorbidities in epilepsy that, like seizures, profoundly influence quality of life and can be difficult to ...
Chan, Alvin Y +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source
Current clinical application of deep-brain stimulation for essential tremor
Neuropsychiatric Disease and Treatment, 2013 Amit Chopra, Bryan T Klassen, Matt Stead Department of Neurology, Mayo Clinic, Rochester, MN, USA Background: Deep-brain stimulation (DBS) is an established treatment for medically refractory essential tremor (ET).
Chopra A, Klassen BT, Stead M
doaj
Washout of chronic therapeutic deep brain stimulation increases cortical phase-amplitude coupling. [PDF]
, 2019 Invasive human brain recordings have shown that acute therapeutic deep brain stimulation (DBS) reduces cortical synchronization, measured by coupling of beta phase to gamma amplitude.
de Hemptinne, Coralie +5 more
core