Results 71 to 80 of about 4,101,096 (348)

Comparison of Common Deep Drawing Steel Sheets in terms of Blank Holder Force and Friction Conditions

International Journal of Automotive Science and Technology, 2018
In this study, it is aimed to make comparison of four different steel sheet materials that are widely used in deep drawing applications by taking blank holder force and friction conditions into account.
M. Emin Erdi̇n, Özgür Özdi̇lli̇
doaj   +1 more source

Deep-Drawing and Fatigue Properties of Advanced Steel Sheet Stripes

, 2010
Analysis of the deep drawing and fatigue properties is given in this contribution for two advanced micro alloyed sheet steel grades with Yield strength values Re 246 and 382 MPa, respectively. The 2 mm thick steel sheets were hot dip zinc coated.
Marian Bursak, Jan Michel
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Modeling of Texture Development during Metal Forming Using Finite Element Visco-Plastic Self-Consistent Model

Crystals
In directional forming processes, such as rolling and extrusion, the grains can develop preferred crystal orientations. These preferred orientations—the texture—are the main cause for material anisotropy. This anisotropy leads to phenomena such as earing,
Johannes Kronsteiner, Elias Theil, Alois Christian Ott, Aurel Ramon Arnoldt, Nikolaus Peter Papenberg   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Study of Parameters Influencing Wrinkles in the Deep Drawing of Fiber-Based Materials Using Automatic Image Detection

Journal of Manufacturing and Materials Processing
The evaluation of wrinkles in deep-drawn fiber-based materials is crucial for the assessment of product quality and the optimization of manufacturing processes.
Yuchen Leng, Cedric Wilfried Sanjon, Qingxiang Tan, Peter Groche, Marek Hauptmann, Jens-Peter Majschak   +5 more
doaj   +1 more source

Tiefziehen mit lokaler Kaltverfestigung auf digitalen mehrachsigen Servopressen

, 2022
S.812-820The paper discusses a new drawing technology, based on a synchronized movement of ram and cushion with multiple bending operations in alternating directions called ""Bi-Directional-Deep Drawing"" (BDD).
Landgrebe, Dirk, Kriechenbauer, Sebastian, Mauermann, Reinhard   +2 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source