Results 81 to 90 of about 4,930,664 (350)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Modeling of Texture Development during Metal Forming Using Finite Element Visco-Plastic Self-Consistent Model

Crystals
In directional forming processes, such as rolling and extrusion, the grains can develop preferred crystal orientations. These preferred orientations—the texture—are the main cause for material anisotropy. This anisotropy leads to phenomena such as earing,
Johannes Kronsteiner, Elias Theil, Alois Christian Ott, Aurel Ramon Arnoldt, Nikolaus Peter Papenberg   +4 more
doaj   +1 more source

Aluminium sheet forming at elevated temperatures [PDF]

, 2001
The formability of aluminum sheet depends on the temperature of the material and the strain\ud rate. E.g. the limiting drawing ratio can be improved by increasing the temperature uniformly, but even more by\ud heating the flange and cooling the punch. To
Bolt, P.J., Boogaard, A.H. van den, Werkhoven, R.J.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Study of Parameters Influencing Wrinkles in the Deep Drawing of Fiber-Based Materials Using Automatic Image Detection

Journal of Manufacturing and Materials Processing
The evaluation of wrinkles in deep-drawn fiber-based materials is crucial for the assessment of product quality and the optimization of manufacturing processes.
Yuchen Leng, Cedric Wilfried Sanjon, Qingxiang Tan, Peter Groche, Marek Hauptmann, Jens-Peter Majschak   +5 more
doaj   +1 more source

Numerical analysis of hot deep drawing of din 27MNCRB5 steel sheets under controlled stretching [PDF]

, 2013
Hot stamping has been widely studied and increasingly applied in the automotive industry. This process is characterized by its ability to stamp high strength steels, yielding products with high mechanical strength, thus ...
Batalha, Mario H. F., Button, Sergio T.
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Influence of alternating bending on springback behavior of parts in deep drawing process with macro-structured tools

MATEC Web of Conferences, 2018
In today’s industry, waste prevention and an efficient use of resources are becoming more important due to economic and environmental requirements. Especially in forming processes such as deep drawing, a reduced use of lubricants is highly promising for ...
Mousavi Ali, Ridolfi Kevin Sven, Brosius Alexander   +2 more
doaj   +1 more source

BBQ-Networks: Efficient Exploration in Deep Reinforcement Learning for Task-Oriented Dialogue Systems

, 2017
We present a new algorithm that significantly improves the efficiency of exploration for deep Q-learning agents in dialogue systems. Our agents explore via Thompson sampling, drawing Monte Carlo samples from a Bayes-by-Backprop neural network.
Ahmed, Faisal, Deng, Li, Gao, Jianfeng, Li, Lihong, Li, Xiujun, Lipton, Zachary C.   +5 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source