Results 81 to 90 of about 1,059,912 (346)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Influence of alternating bending on springback behavior of parts in deep drawing process with macro-structured tools

MATEC Web of Conferences, 2018
In today’s industry, waste prevention and an efficient use of resources are becoming more important due to economic and environmental requirements. Especially in forming processes such as deep drawing, a reduced use of lubricants is highly promising for ...
Mousavi Ali, Ridolfi Kevin Sven, Brosius Alexander   +2 more
doaj   +1 more source

Study of Deep Drawing Combined with Ironing of A7075 Aluminum Alloy [PDF]

MATEC Web of Conferences
This study focuses on the process analysis and pass design of compound deep drawing with ironing processes of A7075 aluminum alloy. At first, A7075-T6 aluminum alloy workpiece is annealed to enhance the formability.
Hwang Yeong-Maw, Wu Yen-Lin, Wang Cheng-Chi   +2 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Forming Behaviour in Laser Shock Drawing [PDF]

, 2008
Through the continuing trend of miniaturization new cost efficient and fast methods for processing small parts are required. In this paper a new non-mechanical process for the forming process of micro deep drawing is presented.
Schulze Niehoff, H., Vollertsen, F., Wielage, H.   +2 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Tailoring Thermal Energy Supply Towards the Advanced Control of Deformation Mechanisms in 3D Forming of Paper and Board

Journal of Manufacturing and Materials Processing
The temperature of the tools and the moisture content of the material play a significant role in the 3D forming of paperboard in terms of the degree of forming and the quality of the formed part.
Leonard Vogt, Marek Hauptmann
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Recent developments in finite element simulations of the deep drawing process [PDF]

, 1997
Some new developments in a finite element code for the deep drawing process are presented\ud in this paper. First the phenomenon of friction is treated.
Carleer, B.D., Huetink, J., Meinders, T., Vegter, H.   +3 more
core   +1 more source

Metal Laminated Tooling - A Quick and Flexible Tooling Concept [PDF]

, 2004
For the fast manufacturing of complex formed tools Fraunhofer IWS works together with partners from the industry on a constant automation solution for cutting, packaging and adding steel sheet cutouts.
Beyer, Eckhard, Himmer, Thomas, Nowotny, Steffen, Techel, Anja   +3 more
core   +1 more source