Results 1 to 10 of about 471,791 (141)

Deep-Sea Natural Products from Extreme Environments: Cold Seeps and Hydrothermal Vents [PDF]

Marine Drugs, 2022
The deep sea has been proven to be a great treasure for structurally unique and biologically active natural products in the last two decades. Cold seeps and hydrothermal vents, as typical representatives of deep-sea extreme environments, have attracted ...
Mengjing Cong, Xiaoyan Pang, Kai Zhao, Yue Song, Yonghong Liu, Junfeng Wang   +5 more
doaj   +2 more sources

A Chemometric Analysis of Deep-Sea Natural Products [PDF]

Molecules, 2019
Deep-sea natural products have been created by unique marine organisms that thrive in a challenging environment of extreme conditions for its inhabitants.
Lisa I. Pilkington
doaj   +2 more sources

OSMAC guided bioprospecting of Atlantic sponges reveals novel bacterial species and evidence for the antimicrobial thiazole alkaloid agrochelin II [PDF]

Applied and Environmental Microbiology
The deep sea remains a major reservoir of underexplored microbial diversity and biosynthetic novelty. Here, we describe three bacterial species isolated from Atlantic sponges, including Stappia quadratibracata sp. nov., Bacillus crepusculi sp.
Sam E. Williams, Henry L. Stennett, Andrew J. Devine, Zhongshu Song, Catherine R. Back, Luoyi Wang, Judith Mantell, Chris Neal, Mark A. Jepson, Angela E. Essex-Lopresti, Jonathan D. Sellars, James E. M. Stach, Christine L. Willis, Paul Curnow, Paul R. Race   +14 more
doaj   +2 more sources

Oil degradation and biosurfactant production by the deep sea bacterium Dietzia maris As-13-3 [PDF]

Frontiers in Microbiology, 2014
: Recent investigations of extreme environments have revealed numerous bioactive natural products. However, biosurfactant-producing strains from deep sea extreme environment are largely unknown. Here, we show that Dietzia maris As-13-3 isolated from deep
Wanpeng eWang, Zongze eShao, bobo eCai
doaj   +4 more sources

Deep-Sea-Derived Fungi as Valuable Producers of Cytotoxic Secondary Metabolites and Their Leads Potential

Frontiers in Marine Science, 2022
Cancer is the leading lethal disease worldwide. Natural products have contributed significantly to the development of approved therapeutic agents. Therefore, research into new bioactive naturally sourced metabolites with lead potential is urgently needed.
Guangrong Zhao, Guangrong Zhao, Wenli Tang, Jianlong Zhang, Jianlong Zhang, Jianlong Zhang, Peimin Shi, Youzhi Li, Jiao Wang, Jiao Wang, Qingqin Shen, Haixia Si, Linlin Jiang, Linlin Jiang, Linlin Jiang, Xin Yu, Xin Yu, Xin Yu, Hongwei Zhu, Hongwei Zhu, Hongwei Zhu, Guozhong Chen, Guozhong Chen, Xingxiao Zhang, Xingxiao Zhang, Xingxiao Zhang, Hong Jia   +26 more
doaj   +1 more source

Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022

Frontiers in Marine Science, 2023
The marine environment can harbor millions of macro- and micro-organisms. These habitats have gained more attention as it was found they produce a plethora of novel secondary metabolites.
Zimin Wang, Zimin Wang, Mallique Qader, Yufei Wang, Fandong Kong, Qi Wang, Cong Wang   +6 more
doaj   +1 more source

A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge

Marine Drugs, 2021
To tackle the growing problem of antibiotic resistance, it is essential to identify new bioactive compounds that are effective against resistant microbes and safe to use.
Catherine R. Back, Henry L. Stennett, Sam E. Williams, Luoyi Wang, Jorge Ojeda Gomez, Omar M. Abdulle, Thomas Duffy, Christopher Neal, Judith Mantell, Mark A. Jepson, Katharine R. Hendry, David Powell, James E. M. Stach, Angela E. Essex-Lopresti, Christine L. Willis, Paul Curnow, Paul R. Race   +16 more
doaj   +1 more source

Actinobacteria from Arctic and Atlantic deep-sea sediments—Biodiversity and bioactive potential

Frontiers in Microbiology, 2023
The deep-sea covers over 70% of the Earth’s surface and harbors predominantly uncharacterized bacterial communities. Actinobacteria are the major prokaryotic source of bioactive natural products that find their way into drug discovery programs, and the ...
Inês Ribeiro, Inês Ribeiro, Jorge T. Antunes, Diogo A. M. Alexandrino, Diogo A. M. Alexandrino, Maria Paola Tomasino, Eduarda Almeida, Eduarda Almeida, Ana Hilário, Ralph Urbatzka, Pedro N. Leão, Ana P. Mucha, Ana P. Mucha, Maria F. Carvalho, Maria F. Carvalho   +14 more
doaj   +1 more source

A Treasure of Bioactive Compounds from the Deep Sea

Biomedicines, 2021
The deep-sea environment is a unique, challenging extreme habitat where species have had to adapt to the absence of light, low levels of oxygen, high pressure and little food.
Assunta Saide, Chiara Lauritano, Adrianna Ianora   +2 more
doaj   +1 more source

The Diversity of Deep-Sea Actinobacteria and Their Natural Products: An Epitome of Curiosity and Drug Discovery

Diversity, 2022
Bioprospecting of novel antibiotics has been the conventional norm of research fostered by researchers worldwide to combat drug resistance. With the exhaustion of incessant leads, the search for new chemical entities moves into uncharted territories such
Galana Siro, Lavinia Donald, Atanas Pipite   +2 more
doaj   +1 more source