Results 11 to 20 of about 471,933 (277)

Bioprospecting Deep-Sea Actinobacteria for Novel Anti-infective Natural Products [PDF]

Frontiers in Microbiology, 2018
The global prevalence of drug resistance has created an urgent need for the discovery of novel anti-infective drugs. The major source of antibiotics in current clinical practice is terrestrial actinobacteria; the less-exploited deep-sea actinobacteria ...
Dongbo Xu, Linna Han, Chunhui Li, Chunhui Li, Qi Cao, Duolong Zhu, Nolan H. Barrett, Dedra Harmody, Jing Chen, Haining Zhu, Peter J. McCarthy, Xingmin Sun, Guojun Wang   +12 more
doaj   +3 more sources

The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products [PDF]

Antibiotics, 2020
The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored.
Sam E. Williams, Henry L. Stennett, Catherine R. Back, Kavita Tiwari, Jorge Ojeda Gomez, Martin R. Challand, Katharine R. Hendry, James Spencer, Angela E. Essex-Lopresti, Christine L. Willis, Paul Curnow, Paul R. Race   +11 more
doaj   +5 more sources

Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential

FEMS Microbes, 2023
Abstract Global antimicrobial resistance is a health crisis that can change the face of modern medicine. Exploring diverse natural habitats for bacterially-derived novel antimicrobial compounds has historically been a successful strategy.
Poppy J Hesketh-Best, Grant G January, Matthew J Koch, Philip J Warburton, Kerry L Howell, Mathew Upton   +5 more
openaire   +2 more sources

Unveiling the Chemical Diversity of the Deep-Sea Sponge Characella pachastrelloides

Marine Drugs, 2022
Sponges are at the forefront of marine natural product research. In the deep sea, extreme conditions have driven secondary metabolite pathway evolution such that we might expect deep-sea sponges to yield a broad range of unique natural products. Here, we
Sam Afoullouss, Anthony R. Sanchez, Laurence K. Jennings, Younghoon Kee, A. Louise Allcock, Olivier P. Thomas   +5 more
doaj   +1 more source

Occurrence, sources and transport pathways of natural and anthropogenic hydrocarbons in deep-sea sediments of the eastern Mediterranean Sea [PDF]

Biogeosciences, 2013
Surface sediments collected from deep basins (1018–4087 m depth) of the eastern Mediterranean Sea (Ionian Sea, southern Aegean Sea and northwestern Levantine Sea) were analyzed for aliphatic and polycyclic aromatic hydrocarbons as tracers of natural and ...
C. Parinos, A. Gogou, I. Bouloubassi, R. Pedrosa-Pàmies, I. Hatzianestis, A. Sanchez-Vidal, G. Rousakis, D. Velaoras, G. Krokos, V. Lykousis   +9 more
doaj   +1 more source

Deep-Sea Sponges and Corals off the Western Coast of Florida—Intracellular Mechanisms of Action of Bioactive Compounds and Technological Advances Supporting the Drug Discovery Pipeline

Marine Drugs, 2023
The majority of natural products utilized to treat a diverse array of human conditions and diseases are derived from terrestrial sources. In recent years, marine ecosystems have proven to be a valuable resource of diverse natural products that are ...
Mina Iskandar, Kira M. Ruiz-Houston, Steven D. Bracco, Sami R. Sharkasi, Cecilia L. Calabi Villarroel, Meghna N. Desai, Alexandra G. Gerges, Natalia A. Ortiz Lopez, Miguel Xiao Barbero, Amelia A. German, Vinoothna S. Moluguri, Selina M. Walker, Juliana Silva Higashi, Justin M. Palma, Daena Z. Medina, Miit Patel, Prachi Patel, Michaela Valentin, Angelica C. Diaz, Jonathan P. Karthaka, Atzin D. Santiago, Riley B. Skiles, Luis A. Romero Umana, Maxwell D. Ungrey, Anya Wojtkowiak, Domenica V. Howard, Remy Nurge, Katharine G. Woods, Meera Nanjundan   +28 more
doaj   +1 more source

Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV–Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1^T

Marine Drugs, 2021
Three dermacozines, dermacozines N–P (1–3), were isolated from the piezotolerant Actinomycete strain Dermacoccus abyssi MT 1.1T, which was isolated from a Mariana Trench sediment in 2006.
Bertalan Juhasz, Dawrin Pech-Puch, Jioji N. Tabudravu, Bastien Cautain, Fernando Reyes, Carlos Jiménez, Kwaku Kyeremeh, Marcel Jaspars   +7 more
doaj   +1 more source

Biodegradability standards for carrier bags and plastic films in aquatic environments: a critical review [PDF]

, 2018
Plastic litter is encountered in aquatic ecosystems across the globe, including polar environments and the deep sea. To mitigate the adverse societal and ecological impacts of this waste, there has been debate on whether ‘biodegradable’ materials should ...
Ardisson GB, Association Française de Normalisation (AFNOR), ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, Bergmann M, De Wilde B, Harrison JP, Imam SH, International Organization for Standardization (ISO), International Organization for Standardization (ISO), International Organization for Standardization (ISO), Müller R-J, Müller R-J, Sharabi NE, The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI)., The British Standards Institution (BSI)., Yabannavar AV   +33 more
core   +4 more sources

Diversity of Natural Product Biosynthetic Genes in the Microbiome of the Deep Sea Sponges Inflatella pellicula, Poecillastra compressa, and Stelletta normani [PDF]

Frontiers in Microbiology, 2016
Three different deep sea sponge species, Inflatella pellicula, Poecillastra compressa, and Stelletta normani comprising seven individual samples, retrieved from depths of 760-2900 m below sea level, were investigated using 454 pyrosequencing for their secondary metabolomic potential targeting adenylation domain and ketosynthase domain sequences.
Borchert, E., Jackson, S., O'Gara, Fergal, Dobson, A.   +3 more
openaire   +4 more sources

Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa [PDF]

Marine Drugs, 2017
The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon.
Alfredo Braña, Aida Sarmiento-Vizcaíno, Miguel Osset, Ignacio Pérez-Victoria, Jesús Martín, Nuria De Pedro, Mercedes De la Cruz, Caridad Díaz, Francisca Vicente, Fernando Reyes, Luis García, Gloria Blanco   +11 more
openaire   +4 more sources