Results 61 to 70 of about 471,933 (277)

Pseudomonassin, a New Bioactive Ribosomally Synthesised and Post-Translationally Modified Peptide from Pseudomonas sp. SST3

Microorganisms, 2023
Genome mining and metabolomics have become valuable tools in natural products research to evaluate and identify potential new chemistry from bacteria. In the search for new compounds from the deep-sea organism, Pseudomonas sp.
Kevin Jace Miranda, Saif Jaber, Dana Atoum, Subha Arjunan, Rainer Ebel, Marcel Jaspars, RuAngelie Edrada-Ebel   +6 more
doaj   +1 more source

Marine crude-oil biodegradation: a central role for interspecies interactions [PDF]

, 2012
The marine environment is highly susceptible to pollution by petroleum, and so it is important to understand how microorganisms degrade hydrocarbons, and thereby mitigate ecosystem damage. Our understanding about the ecology, physiology, biochemistry and
Folwell, Benjamin D, McGenity, Terry J, McKew, Boyd A, Sanni, Gbemisola O   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploring deep-sea Actinomycetota chemical diversity by using the OSMAC approach

Frontiers in Marine Science
The constant need to search for new drugs is a major driver for the discovery of new molecules of pharmaceutical interest. Natural products (NPs) of microbial origin have been recognized for their therapeutic properties, with Actinomycetota being one of ...
Sofia Correia, Sofia Correia, Inês Ribeiro, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Andreia Braga-Henriques, Pedro N. Leão, Ralph Urbatzka, Maria F. Carvalho, Maria F. Carvalho   +11 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Genome Mining and Metabolic Profiling Uncover Polycyclic Tetramate Macrolactams from Streptomyces koyangensis SCSIO 5802

Marine Drugs, 2021
We have previously shown deep-sea-derived Streptomyces koyangensis SCSIO 5802 to produce two types of active secondary metabolites, abyssomicins and candicidins. Here, we report the complete genome sequence of S.
Wenjuan Ding, Jiajia Tu, Huaran Zhang, Xiaoyi Wei, Jianhua Ju, Qinglian Li   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Elaboration of New Method of Deep Processing of Caro-tene-containing Raw Materials Into Nanoadditives with the Use of Cryogenic Freezing and Fine-dispersed Grinding [PDF]

, 2016
The aim of the work is elaboration of principally new cryogenic method of deep processing of carotene-containing vegetable raw material (CCVRM) such as carrot, pumpkin, sweet Bulgarian pepper, tomato, sea buckthorn, apricot using cryogenic freezing and ...
Bilenko, L. (Leonida), Pavlyuk, R. (Raisa), Pogarska, V. (Viktoriya), Stukonozhenko, T. (Tetyana), Timofeyeva, N. (Nadiya)   +4 more
core  

Extensive dissolution of live pteropods in the Southern Ocean [PDF]

, 2012
The carbonate chemistry of the surface ocean is rapidly changing with ocean acidification, a result of human activities. In the upper layers of the Southern Ocean, aragonite—a metastable form of calcium carbonate with rapid dissolution kinetics—may ...
A. Kuzirian, AG Dickson, AG Dickson, B. Lézé, BI McNeil, BPV Hunt, C Le Quere, C Mehrbach, D Roberts, D. C. E. Bakker, E Jones, E. J. Murphy, E. M. Jones, G. A. Tarling, H Jansen, H. J. Venables, J Park, JC Orr, KJ Heywood, KM Johnson, M Kahru, M Steinacher, M Yamamoto-Kawai, N Bednarsek, N Bednarsek, N. Bednaršek, P. Ward, PR Betzer, R Francois, R. A. Feely, RA Feely, RA Feely, RA Feely, RH Byrne, S Comeau, S Comeau, S. Fielding, VJ Fabry, VJ Fabry, WS Broecker   +39 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source