Results 71 to 80 of about 471,933 (277)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Deep- Sea Bacteria And Their Biotechnological Potentials [PDF]
, 2004 Deep-sea environment characterized by its low temperature, high hydrostatic pressure, limited nutrient contents, and constant darkness has been a hostile environment for most marine microorganisms.
Karna Radjasa, Ocky
core
Open ocean carbon monoxide photo-production [PDF]
, 2006 Sunlight-initiated photolysis of chromophoric dissolved organic matter (CDOM) is the dominant source of carbon monoxide (CO) in the open-ocean. A modelling study was conducted to constrain this source.
Law, Cliff S. +5 more
core +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
2017 State-of the Science of Dispersants and Dispersed Oil (DDO) in U.S. Arctic Waters: Degradation and Fate [PDF]
, 2017 Chemical dispersants were employed on an unprecedented scale during the Deepwater Horizon oil spill in the Gulf of Mexico, and could be a response option should a large spill occur in Arctic waters. The use of dispersants in response to that spill raised
Coastal Response Research Center (CRRC)
core +1 more source
A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria [PDF]
, 2020 Predator-prey interactions play important roles in the cycling of marine organic matter. Here we show that a Gram-negative bacterium isolated from marine sediments (Pseudoalteromonas sp.
Chen, Xiu-Lan +16 more
core +2 more sources
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Anthoteibinenes F–Q: New Sesquiterpenes from the Irish Deep-Sea Coral Anthothela grandiflora
Marine DrugsNew technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products.
Stine S. H. Olsen +6 more
doaj +1 more source
Marine Oil Snow Sedimentation and Flocculent Accumulation (MOSSFA) Workshop [PDF]
, 2013 The MOSSFA hypothesis is that the formation of marine snow/oil aggregates and its accumulation at the seafloor is related to events associated with the oil spill, various mitigation measures (e.g., the use of dispersants and in situ burning), and ...
Center for Spills in the Environment
core +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source