Results 71 to 80 of about 2,478,930 (305)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RRS Discovery Cruise 248, 07 Jul-10 Aug 2000. A multidisciplinary study of the environment and ecology of deep-water coral ecosystems and associated seabed facies and features (The Darwin Mounds, Porcupine Bank and Porcupine Seabight) [PDF]

, 2001
RRS Discovery Cruise 248 aimed to carry out a multidisciplinary study of the environment and ecology of deep-water coral ecosystems and associated seabed features in the northeast Atlantic.
Bett, B.J., Billett, D.S.M., Masson, D.G., Tyler, P.A.   +3 more
core  

Collision of two breathers at surface of deep water [PDF]

, 2012
We applied canonical transformation to water wave equation not only to remove cubic nonlinear terms but to simplify drastically fourth order terms in Hamiltonian.
Dyachenko, A. I., Kachulin, D. I., Zakharov, V. E.   +2 more
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Development and Application of the Modularized Ground Test Equipment System for Deep Water Test

Shiyou jixie, 2016
The ground test processes of deepwater testing operation have the issues like high cost,large space needed on drilling platform,lowering the drilling efficiency.Through deepwater testing process modularization design and independent research and ...
Jin Shukai, Zhang Chong, Meng Wenbo, Wang Erjun, Tian Xiangdong, Wei Jianfei   +5 more
doaj  

Extensive dissolution of live pteropods in the Southern Ocean [PDF]

, 2012
The carbonate chemistry of the surface ocean is rapidly changing with ocean acidification, a result of human activities. In the upper layers of the Southern Ocean, aragonite—a metastable form of calcium carbonate with rapid dissolution kinetics—may ...
A. Kuzirian, AG Dickson, AG Dickson, B. Lézé, BI McNeil, BPV Hunt, C Le Quere, C Mehrbach, D Roberts, D. C. E. Bakker, E Jones, E. J. Murphy, E. M. Jones, G. A. Tarling, H Jansen, H. J. Venables, J Park, JC Orr, KJ Heywood, KM Johnson, M Kahru, M Steinacher, M Yamamoto-Kawai, N Bednarsek, N Bednarsek, N. Bednaršek, P. Ward, PR Betzer, R Francois, R. A. Feely, RA Feely, RA Feely, RA Feely, RH Byrne, S Comeau, S Comeau, S. Fielding, VJ Fabry, VJ Fabry, WS Broecker   +39 more
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Sedimentary build-ups of pre-salt isolated carbonate platforms and formation of deep-water giant oil fields in Santos Basin, Brazil

Petroleum Exploration and Development
In response to the problems of unclear distribution of deep-water pre-salt carbonate reservoirs and formation conditions of large oil fields in the Santos passive continental margin basin, based on comprehensive utilization of geological, seismic, and ...
Lirong DOU, Zhixin WEN, Zhaoming WANG, Zhengjun HE, Chengpeng SONG, Ruiyin CHEN, Xiaofa YANG, Xiaobing LIU, Zuodong LIU, Yanyan CHEN   +9 more
doaj   +1 more source

Pore fluid constraints on deep ocean temperature and salinity during the Last Glacial Maximum [PDF]

, 2001
Pore water records of δ^(18)O and [Cl] from ODP Site 1063A on the Bermuda Rise constrain the change in seawater δ^(18)O and salinity from the Last Glacial Maximum (LGM) to the Holocene to be 0.75±0.05‰ and 2.5±0.1% respectively.
Adkins, J. F., Schrag, D. P.
core   +1 more source